Polymer particles

Patent metadata

Field	Value
Publication number	US-12447228-B2
Application number	US-202318112192-A
Country	US
Kind code	B2
Filing date	Feb 21, 2023
Priority date	Sep 28, 2016
Publication date	Oct 21, 2025
Grant date	Oct 21, 2025

Abstract

Described are polymers and methods of forming and using same.

First claim

We claim:

1. A method of treatment comprising:
administering a solution including a plurality of particles to a treatment site;
wherein the plurality of particles include a reaction product of at least one monomer, at least one crosslinker, and at least one polymerizable pharmaceutical agent;
wherein the at least one polymerizable pharmaceutical agent is chemically bonded to the particle with a hydrolytically degradable linkage; and
wherein the at least one polymerizable pharmaceutical agent has a structure which is a polymerizable derivative of 7-ethyl-10-hydroxy-camptothecin.

2. The method of claim 1 , wherein the administering is to fill an aneurysm.

3. The method of claim 1 , wherein the administering is to form an embolus.

4. The method of claim 1 , wherein the administering is to fill a vessel malformation.

5. The method of claim 1 , wherein the administering is to fill a biological void.

6. The method of claim 1 , wherein the administering is to provide a pharmaceutical agent.

7. The method of claim 1 , wherein the treatment site is a vessel.

8. The method of claim 1 , wherein the treatment site is a surgery site.

9. The method of claim 1 , wherein the treatment site is an injury site.

10. The method of claim 1 , wherein the administering is through a catheter, microcatheter, or a needle.

11. The method of claim 1 , wherein the solution includes a visualization agent.

12. The method of claim 1 , wherein the plurality of particles includes a visualization agent chemically incorporated therein.

13. The method of claim 1 further comprising allowing sufficient time for the at least one polymerizable pharmaceutical agent to release form the plurality of particles, wherein the release is about 3% to about 5% of the at least one polymerizable pharmaceutical agent per day.

14. The method of claim 1 , further comprising navigating a delivery device to the treatment site.

15. The method of claim 14 , wherein the delivery device is a catheter, microcatheter, or a needle.

16. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure

17. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure

wherein q is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
X is O or NH; and
X′ is H or CH3.

18. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure

19. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure

20. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure

Assignees

• Terumo Corp

Inventors

• Cruise Gregory M
• Wu Xinping
• Hincapie Gloria
• Wu Yue

Classifications

• C08F236/20

  unconjugated · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• A61L31/048

  obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence) · CPC title

• C08F220/56

  Acrylamide; Methacrylamide · CPC title

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title