Particles

Patent metadata

Field	Value
Publication number	US-10155064-B2
Application number	US-201815878294-A
Country	US
Kind code	B2
Filing date	Jan 23, 2018
Priority date	Mar 26, 2015
Publication date	Dec 18, 2018
Grant date	Dec 18, 2018

Abstract

Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.

First claim

We claim:

1. An embolic system including:
a catheter; and
spherical embolic particles having an organic polymer backbone including a reaction product of a prepolymer solution including:
a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof; and
at least one monomer,

wherein the spherical embolic particles have a diameter between about 50 μm and about 1,500 μm.

2. The embolic system of claim 1 , wherein the diameter is between about 400 μm and about 1,500 μm.

3. The embolic system of claim 1 , wherein the catheter is a microcatheter.

4. The embolic system of claim 1 , wherein the at least one monomer includes ionic groups.

5. The embolic system of claim 4 , wherein the monomer containing ionic groups is sodium acrylate.

6. The embolic system of claim 1 , wherein the prepolymer solution further includes a crosslinker.

7. The embolic system of claim 6 , wherein the crosslinker is biodegradable.

8. The embolic system of claim 6 , wherein the crosslinker has a structure:

wherein each n is independently 1-20;

wherein d, e, f, and g are each independently 1-20; or

9. The embolic system of claim 1 , wherein the spherical embolic particles further include a visualization agent having a structure:

10. A method of treatment, the method comprising:
delivering spherical embolic particles having an organic polymer backbone through a catheter to a treatment site,
wherein the spherical embolic particles are formed from a reaction product of a prepolymer solution including:
a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof; and
at least one monomer,

wherein the spherical embolic particles have a diameter between about 50 μm and about 1,500 μm.

11. The method of claim 10 , wherein the delivering includes flushing the catheter with a non-solvent.

12. The method of claim 11 , wherein the non-solvent is a mineral oil, hexane, or water.

13. The method of claim 11 , wherein the diameter is between about 400 μm and about 1,500 μm.

14. The method of claim 11 , wherein the catheter is a microcatheter.

15. The method of claim 11 , wherein the at least one monomer includes ionic groups.

16. The method of claim 15 , wherein the monomer containing ionic groups is sodium acrylate.

17. The method of claim 11 , wherein the prepolymer solution further includes a crosslinker.

18. The method of claim 17 , wherein the crosslinker is biodegradable.

19. The method of claim 17 , wherein the crosslinker has a structure:

wherein each n is independently 1-20;

wherein d, e, f, and g are each independently 1-20; or

20. The method of claim 11 , wherein the spherical embolic particles further include a visualization agent having a structure:

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Plotkin Steve
• Wu Xinping

Classifications

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title

• A61L24/001

  Use of materials characterised by their function or physical properties · CPC title

• A61L24/06 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} · CPC title

• C08F222/385

  Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide · CPC title

• C08L33/26

  Homopolymers or copolymers of acrylamide or methacrylamide · CPC title