Polymer films

Patent metadata

Field	Value
Publication number	US-9408916-B2
Application number	US-201414491813-A
Country	US
Kind code	B2
Filing date	Sep 19, 2014
Priority date	Sep 19, 2013
Publication date	Aug 9, 2016
Grant date	Aug 9, 2016

Abstract

Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.

First claim

We claim:

1. A polymer film comprising:
at least one monomer including at least one functional group; and
at least one crosslinker selected from bis-glycidyl amino alcohol, bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate,

wherein a, b, c, d, e, and f are each independently 1-20;
wherein the polymer film has a thickness between about 40 μm and about 1,200 μm and is biodegradable.

2. The polymer film of claim 1 , wherein the polymer film has a shape selected from a circle, square, rectangle, triangle, ellipse, or pentagon.

3. The polymer film of claim 1 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.

4. The polymer film of claim 1 , wherein the at least one monomer includes an ionizable functional group.

5. The polymer film of claim 4 , wherein the ionizable functional group is basic.

6. The polymer film of claim 4 , wherein the ionizable functional group is acidic.

7. The polymer film of claim 1 , wherein the at least one crosslinker includes at least two functional groups.

8. The polymer film of claim 1 , wherein the crosslinker includes at least one linkage susceptible to degradation through hydrolysis or enzymatic action.

9. The polymer film of claim 8 , wherein the at least one linkage is an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenase, a peptide cleavable by matrix elastase, a peptide cleavable by matrix cathepsin, or a combination thereof.

10. The polymer film of claim 9 , including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.

11. The polymer film of claim 1 , wherein the polymer film is substantially degraded within about 6 months of implantation.

12. The polymer film of claim 1 , wherein the polymer film is substantially degraded within about 1 month of implantation.

13. The polymer film of claim 1 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.

14. The polymer film of claim 1 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.

15. A method of making a polymer film comprising:
reacting a prepolymer solution including at least one monomer including at least one functional group, at least one crosslinker susceptible to degradation, and an initiator; and
forming the polymer film, wherein the polymer film has a thickness between about 40 μm and about 1,200 μm,
wherein the at least one crosslinker is selected from bis-glycidyl amino alcohol, bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate,

wherein a, b, c, d, e, and f are each independently 1-20.

16. The method of claim 15 , wherein the film is formed between two plates including at least one spacer.

17. The method of claim 15 , wherein the initiator is N,N,N′,N′-tetramethylethylenediamine.

18. The method of claim 15 , wherein the polymer film has a shape selected from a circle, square, rectangle, triangle, ellipse, or pentagon.

19. The method of claim 15 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.

20. The method of claim 15 , wherein the polymer film is biodegradable.

21. The method of claim 20 , wherein the polymer film is substantially degraded within about 1 month of implantation.

22. The method of claim 20 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.

23. The method of claim 20 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Hincapie Gloria
• Harris Clayton
• Wu Yue

Classifications

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• A61K47/32 Primary

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title

• C08F120/56 Primary

  Acrylamide; Methacrylamide · CPC title

• C08J2333/14

  of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen · CPC title

• C08F220/56

  Acrylamide; Methacrylamide · CPC title