Polymer particles

Patent metadata

Field	Value
Publication number	US-10201632-B2
Application number	US-201715719241-A
Country	US
Kind code	B2
Filing date	Sep 28, 2017
Priority date	Sep 28, 2016
Publication date	Feb 12, 2019
Grant date	Feb 12, 2019

Abstract

Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

First claim

We claim:

1. A polymer particle comprising:
at least one monomer including at least one functional group; and
at least one crosslinker having a structure

2. The polymer particle of claim 1 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.

3. The polymer particle of claim 1 , wherein the polymer particle has a diameter between about 75 μm and about 1,200 μm.

4. The polymer particle of claim 1 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.

5. The polymer particle of claim 1 , wherein the at least one monomer includes an ionizable functional group.

6. The polymer particle of claim 5 , wherein the ionizable functional group is basic.

7. The polymer particle of claim 5 , wherein the ionizable functional group is acidic.

8. The polymer particle of claim 1 , wherein the at least one crosslinker includes at least two functional groups.

9. The polymer particle of claim 1 , including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.

10. The polymer particle of claim 1 , wherein the polymer particle is biodegradable.

11. The polymer particle of claim 1 , wherein the polymer particle is substantially degraded within about 1 week of implantation.

12. The polymer particle of claim 1 , wherein the at least one monomer is dimethylacrylamide.

13. The polymer particle of claim 1 , wherein the at least one monomer is acrylamide.

14. A method of making a polymer particle comprising:
reacting a prepolymer solution including at least one monomer including at least one functional group, at least one crosslinker having a structure

and an initiator in an oil; and
forming the polymer particle.

15. The method of claim 14 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.

16. The method of claim 14 , wherein the oil is mineral oil.

17. The method of claim 14 , wherein the initiator is azobisisobutyronitrile.

18. The method of claim 14 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.

19. The method of claim 14 , wherein the polymer particle is biodegradable.

20. The method of claim 14 , wherein the polymer particle is substantially degraded within about 1 week of implantation.

Assignees

• Microvention Inc
• Terumo Corp

Inventors

• Hincapie Gloria
• Wu Xinping
• Wu Yue
• Cruise Gregory M

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P7/02

  Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title