Polymer particles

Patent metadata

Field	Value
Publication number	US-9938367-B2
Application number	US-201715630048-A
Country	US
Kind code	B2
Filing date	Jun 22, 2017
Priority date	Sep 19, 2013
Publication date	Apr 10, 2018
Grant date	Apr 10, 2018

Abstract

Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

First claim

We claim:

1. An embolic system including:
a delivery device; and
an embolic solution including polymer particles, wherein the polymer particles include:
an acrylate, acrylamide, methacrylamide, methyl methacrylate, or a combination thereof, and
a crosslinker,

wherein the polymer particles have a spherical diameter between about 40 μm and about 1,200 μm.

2. The embolic system of claim 1 , wherein the polymer particles are susceptible to degradation through hydrolysis or enzymatic action, and wherein the degradation provides less than about 10% of the polymer particles intact after about 5 days.

3. The embolic system of claim 1 , wherein the spherical diameter is between about 75 μm and about 1,200 μm.

4. The embolic system of claim 1 , wherein the crosslinker includes at least two functional groups.

5. The embolic system of claim 1 , wherein the crosslinker includes at least one linkage susceptible to degradation through hydrolysis or enzymatic action.

6. The embolic system of claim 1 , wherein the crosslinker is bis-glycidyl amino alcohol,

wherein a, b, c, d, e, and f are each independently 1-20.

7. The embolic system of claim 5 , wherein the at least one linkage is an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, a peptide cleavable by matrix cathepsins, or a combination thereof.

8. The embolic system of claim 1 , including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.

9. The embolic system of claim 1 , wherein the crosslinker is bis-glycidyl amino alcohol or bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.

10. The embolic system of claim 1 , wherein the delivery device is a catheter.

11. The embolic system of claim 1 , wherein the delivery device is a microcatheter.

12. The embolic system of claim 1 , wherein the delivery device is a needle.

13. The embolic system of claim 1 , wherein the delivery device and the embolic solution are sterilized.

14. The embolic system of claim 1 , wherein the embolic solution includes a monomer including an ionizable functional group.

15. The embolic system of claim 14 , wherein the ionizable functional group is basic or acidic.

16. The embolic system of claim 1 , wherein the embolic solution includes a radiopaque contrast agent.

17. The embolic system of claim 1 , wherein the embolic solution includes a dye.

18. The embolic system of claim 1 , wherein the embolic solution is provided in a vial.

19. The embolic system of claim 1 , wherein the embolic solution is provided in a syringe.

20. The embolic system of claim 1 , wherein the polymer particles have a circularity greater than about 0.9.

Assignees

• Terumo Corp

Inventors

• Cruise Gregory M
• Hincapie Gloria
• Harris Clayton

Classifications

• C08F222/408

  substituted imides comprising other heteroatoms · CPC title

• C08F220/56

  Acrylamide; Methacrylamide · CPC title

• C08K5/16

  Nitrogen-containing compounds {(C08K5/0091 takes precedence)} · CPC title

• C08L2201/06

  Biodegradable · CPC title

• Y10T428/2982

  Particulate matter [e.g., sphere, flake, etc.] · CPC title