Polymer filaments including pharmaceutical agents and delivering same

Patent metadata

Field	Value
Publication number	US-10226533-B2
Application number	US-201514678514-A
Country	US
Kind code	B2
Filing date	Apr 3, 2015
Priority date	Apr 29, 2014
Publication date	Mar 12, 2019
Grant date	Mar 12, 2019

Abstract

Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer and at least one visualization agent; and an active agent electrostatically bound to the polymer filament or chemically bound to the at least one monomer; wherein the polymer filament does not include metallic support members.

First claim

We claim:

1. A polymer filament comprising:
a reaction product of a prepolymer solution including at least one macromer including at least three reactive moieties per molecule, a polymerizable pharmaceutical agent, and at least one iodine-containing molecule;
wherein the at least one macromer is ethoxylated pentaerythritol, ethoxylated trimethylolpropane, or a combination thereof;
wherein the polymerizable pharmaceutical agent has a structure

wherein R 1 is

wherein each R 2 and R 3 can independently be H, CH 3 , C 2 -C 6 alkyl, C 2 -C 6 substituted with a halogen or other C 1 -C 6 alkyl, NH 2 , CO 2 , CN, CF 3 , F, Cl, Br, I, CCl 3 , OH, or CH 2 OH;
n is 1, 2, 3, or 4;

m is 1, 2, 3, or 4;
X 1 , X 2 , X 3 , and X 4 are each N or CH; and
X 5 is O, CH 2 , or NH; and
p is 0, 1, 2, 3 or 4.

2. The polymer filament of claim 1 , further comprising at least one monomer selected from t-butyl acrylamide, 2-hydroxyethyl methacrylate, hydroxyl propyl acrylate, hydroxyl butylacrylate, or a combination thereof.

3. The polymer filament of claim 2 , wherein the at least one monomer has a concentration of between about 5% and about 40% w/w of the prepolymer solution.

4. The polymer filament of claim 1 , wherein the at least one macromer has a concentration of between about 15% and about 25% w/w of the prepolymer solution.

5. The polymer filament of claim 1 , wherein the at least one macromer has a molecular weight of between about 100 g/mole and about 5,000 g/mole.

6. The polymer filament of claim 1 , wherein the polymer filament does not include metallic support members.

7. The polymer filament of claim 1 , wherein the polymer filament is configured for delivery through a catheter.

8. A polymer filament comprising:
a reaction product of a prepolymer solution including at least one macromer including at least three reactive moieties per molecule, a polymerizable pharmaceutical agent, and at least one iodine-containing molecule;
wherein the at least one macromer is ethoxylated pentaerythritol, ethoxylated trimethylolpropane, or a combination thereof; and
wherein the polymerizable pharmaceutical agent has a structure

9. The polymer filament of claim 8 , further comprising at least one monomer selected from t-butyl acrylamide, 2-hydroxyethyl methacrylate, hydroxyl propyl acrylate, hydroxyl butylacrylate, or a combination thereof.

10. The polymer filament of claim 9 , wherein the at least one monomer has a concentration of between about 5% and about 40% w/w of the prepolymer solution.

11. The polymer filament of claim 8 , wherein the at least one macromer has a concentration of between about 15% and about 25% w/w of the prepolymer solution.

12. The polymer filament of claim 8 , wherein the at least one macromer has a molecular weight of between about 100 g/mole and about 5,000 g/mole.

13. The polymer filament of claim 8 , wherein the polymer filament does not include metallic support members.

14. The polymer filament of claim 8 , wherein the polymer filament is configured for delivery through a catheter.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Harris Clayton G
• Constant Michael J

Classifications

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61K47/58

  obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title