Polymer particles

Patent metadata

Field	Value
Publication number	US-12364786-B2
Application number	US-202318230569-A
Country	US
Kind code	B2
Filing date	Aug 4, 2023
Priority date	Sep 28, 2016
Publication date	Jul 22, 2025
Grant date	Jul 22, 2025

Abstract

Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

First claim

We claim:

1. A polymer particle, comprising:
a reaction product of a prepolymer solution including a solvent, at least one monomer, and at least one crosslinker having a structure:

wherein m is 0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15, and n is 1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or 18;

wherein p is 0, 1, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15;

wherein q is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15, and r is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15;

wherein s is 0, 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15;

wherein t is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15, and u is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15;

wherein v is 0, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15; or

wherein w is 0, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

2. The polymer particle of claim 1 having a diameter between about 40 μm and about 1,200 μm.

3. The polymer particle of claim 1 having a diameter between about 75 μm and about 1,200 μm.

4. The polymer particle of claim 1 , wherein the at least one monomer includes at least one functional group.

5. The polymer particle of claim 4 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.

6. The polymer particle of claim 1 , wherein the at least one monomer includes an ionizable functional group.

7. The polymer particle of claim 1 , wherein the prepolymer solution further includes a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.

8. The polymer particle of claim 1 , wherein the polymer particles are biodegradable.

9. The polymer particle of claim 1 , wherein the polymer particles are biostable.

10. The polymer particle of claim 1 , wherein the at least one monomer is dimethylacrylamide.

11. The polymer particle of claim 1 , wherein the at least one monomer is acrylamide.

12. The polymer particle of claim 1 , wherein the at least one crosslinker has a structure

wherein m is 0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15, and n is 1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or 18.

13. The polymer particle of claim 1 , wherein the at least one crosslinker has a structure

wherein p is 0, 1, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

14. The polymer particle of claim 1 , wherein the at least one crosslinker has a structure

wherein q is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15, and r is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

15. The polymer particle of claim 1 , wherein the at least one crosslinker has a structure

wherein s is 0, 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

16. The polymer particle of claim 1 , wherein the at least one crosslinker has a structure

wherein t is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15, and u is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

17. The polymer particle of claim 1 , wherein the at least one crosslinker has a structure

wherein v is 0, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

18. The polymer particle of claim 1 , wherein the at least one crosslinker has a structure

wherein w is 0, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

19. The polymer particle of claim 1 , wherein the at least one crosslinker has a structure

wherein v is 1.

20. The polymer particle of claim 1 , wherein the at least one crosslinker has a structure

wherein p is 1.

Assignees

• Terumo Corp

Inventors

• Hincapie Gloria
• Wu Xinping
• Wu Yue
• Cruise Gregory M

Classifications

• C08F236/20

  unconjugated · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• A61L31/048

  obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence) · CPC title

• C08F220/56

  Acrylamide; Methacrylamide · CPC title

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title