Polymer particles

Patent metadata

Field	Value
Publication number	US-12077622-B2
Application number	US-202217583028-A
Country	US
Kind code	B2
Filing date	Jan 24, 2022
Priority date	Nov 8, 2013
Publication date	Sep 3, 2024
Grant date	Sep 3, 2024

Abstract

Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.

First claim

We claim:

1. A polymer particle, wherein the polymer particle comprises a reaction product of a prepolymer solution comprising:
A) at least one polyether,
a glycerol monomethacrylate, and
an amino ethyl methacrylate; or

B) at least one polyether,
an amino propyl methacrylamide, and
a sulfopropyl acrylate.

2. The polymer particle of claim 1 , wherein the polymer particle is a spherical polymer particle.

3. The polymer particle of claim 1 , wherein the polymer particle has a diameter less than about 1,200 μm.

4. The polymer particle of claim 1 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.

5. The polymer particle of claim 1 , wherein the polymer particle is a spherical polymer particle and has a diameter between about 40 μm and about 1,200 μm.

6. The polymer particle of claim 1 , wherein the polymer particle is a desiccated polymer particle or a hydrated polymer particle.

7. The polymer particle of claim 1 , wherein the polymer particle comprises a reaction product of a prepolymer solution comprising:
the at least one polyether at a concentration of between about 15% w/w and about 50% w/w and an initiator in an oil.

8. The polymer particle of claim 7 , wherein the prepolymer solution is an aqueous prepolymer solution, the oil is a mineral oil, and the initiator is ammonium persulfate, tetramethylethylene diamine, or a combination thereof.

9. The polymer particle of claim 1 , wherein the polymer particle comprises a reaction product of a prepolymer solution comprising:
A) poly(ethylene glycol) 10,000 diacrylamide,
a glycerol monomethacrylate, and
a 2-amino ethyl methacrylate; or

B) poly(ethylene glycol) 10,000 diacrylamide,
an n-(3-amino propyl) methacrylamide, and
a 3-sulfopropyl acrylate.

10. The polymer particle of claim 1 , wherein the at least one polyether is a derivatized poly(ethylene glycol), poly(propylene glycol), poly(tetramethylene oxide), or a combination thereof.

11. The polymer particle of claim 1 , wherein the prepolymer solution does not comprise n-isopropyl acrylamide.

12. The polymer particle of claim 1 , wherein the sulfopropyl acrylate is 3-sulfopropyl acrylate.

13. The polymer particle of claim 1 , wherein the prepolymer solution further comprises at least one of the glycerol monomethacrylate, the amino ethyl methacrylate, the amino propyl methacrylamide, or the sulfopropyl acrylate at a concentration of about 50-80% w/w.

14. The polymer particle of claim 1 , wherein the prepolymer solution further comprises at least one of the glycerol monomethacrylate, the amino ethyl methacrylate, the amino propyl methacrylamide, or the sulfopropyl acrylate at a concentration of about 67-73% w/w.

15. The polymer particle of claim 1 , wherein the prepolymer solution further comprises:
the amino propyl methacrylamide at a concentration of about 1% w/w; or
the amino ethyl methacrylate at a concentration of about 3% w/w.

16. The polymer particle of claim 1 , wherein the at least one polyether is poly(ethylene glycol) diacrylamide 10,000 at a concentration of between about 15% w/w and about 50% w/w.

17. The polymer particle of claim 1 , wherein the at least one polyether is poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, or a combination thereof.

18. The polymer particle of claim 1 , wherein the at least one polyether is poly(ethylene glycol) diacrylamide 10,000.

19. The polymer particle of claim 1 , wherein the polymer particle comprises a reaction product of a prepolymer solution comprising:
poly(ethylene glycol) 10,000 diacrylamide,
a glycerol monomethacrylate, and
a 2-amino ethyl methacrylate.

20. The polymer particle of claim 1 , wherein the polymer particle comprises a reaction product of a prepolymer solution comprising:
poly(ethylene glycol) 10,000 diacrylamide,
an n-(3-aminopropyl)methacrylamide hydrochloride, and
a 3-sulfopropyl acrylate potassium salt.

Assignees

• Terumo Corp

Inventors

• Plotkin Steve
• Cruise Gregory M
• Keeley Edward Michael
• Yu Renee
• Harris Clayton

Classifications

• C08F220/10

  Esters · CPC title

• C08G65/33324

  acyclic · CPC title

• A61L2300/418

  Agents promoting blood coagulation, blood-clotting agents, embolising agents · CPC title

• A61L24/06

  obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} · CPC title

• A61L24/0015

  Medicaments; Biocides · CPC title