Methods of treatment comprising administering polymer particles configured for intravascular delivery of pharmaceutical agents

Patent metadata

Field	Value
Publication number	US-11617814-B2
Application number	US-202016913864-A
Country	US
Kind code	B2
Filing date	Jun 26, 2020
Priority date	Sep 28, 2016
Publication date	Apr 4, 2023
Grant date	Apr 4, 2023

Abstract

Described herein are polymeric particles configured for intravascular delivery of pharmaceutical agents, e.g., to a diseased site, and methods of forming and using same. Preparation of these polymer particles is also described.

First claim

We claim:

1. A method of treatment comprising:
administering a solution including a plurality of particles to a treatment site, wherein the plurality of particles include a reaction product of at least one monomer, at least one crosslinker, and at least one polymerizable pharmaceutical agent, wherein the at least one polymerizable pharmaceutical agent is chemically bonded to the particle with a hydrolytically degradable linkage;
wherein the at least one polymerizable pharmaceutical agent has a structure

wherein
n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
p is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
R is O or NH; and
R′ is H or CH 3 .

2. The method of claim 1 , wherein the administering is to fill an aneurysm.

3. The method of claim 1 , wherein the administering is to form an embolus.

4. The method of claim 1 , wherein the administering is to fill a vessel malformation.

5. The method of claim 1 , wherein the administering is to fill a biological void.

6. The method of claim 1 , wherein the administering is to provide a pharmaceutical agent.

7. The method of claim 1 , wherein the treatment site is a vessel.

8. The method of claim 1 , wherein the treatment site is a surgery site.

9. The method of claim 1 , wherein the treatment site is an injury site.

10. The method of claim 1 , wherein the administering is through a catheter, microcatheter, or a needle.

11. The method of claim 1 , wherein the solution includes a visualization agent.

12. The method of claim 1 , wherein the plurality of particles includes a visualization agent chemically incorporated therein.

13. The method of claim 1 , further comprising allowing sufficient time for the at least one polymerizable pharmaceutical agent to release form the plurality of particles, wherein the release is about 3% to about 5% of the at least one polymerizable pharmaceutical agent per day.

14. The method of claim 1 , further comprising navigating a delivery device to the treatment site.

15. The method of claim 14 , wherein the delivery device is a catheter, microcatheter, or a needle.

16. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure

17. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure

18. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure

Assignees

• Terumo Corp

Inventors

• Cruise Gregory M
• Wu Xinping
• Hincapie Gloria
• Wu Yue

Classifications

• A61L2300/224

  containing metals, e.g. porphyrins, vitamin B12 · CPC title

• A61K31/4745 Primary

  condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines (yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48) · CPC title

• A61L24/0042

  Materials resorbable by the body · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• C08F236/20

  unconjugated · CPC title