Polymer films

Patent metadata

Field	Value
Publication number	US-10227463-B2
Application number	US-201615199633-A
Country	US
Kind code	B2
Filing date	Jun 30, 2016
Priority date	Sep 19, 2013
Publication date	Mar 12, 2019
Grant date	Mar 12, 2019

Abstract

Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.

First claim

We claim:

1. A polymer film comprising:
at least one monomer including at least one functional group selected from acrylate, acrylamide, methacrylate, or methacrylamide; and
at least one glycidyl, carbonate, carbamate, TMP gly ester, thioester, or jeffamine glycidyl amine crosslinker including at least one linkage susceptible to degradation through hydrolysis or enzymatic action.

2. The polymer film of claim 1 , wherein the at least one monomer includes an ionizable functional group.

3. The polymer film of claim 2 , wherein the ionizable functional group is basic or acidic.

4. The polymer film of claim 1 , wherein the at least one glycidyl, carbonate, carbamate, TMP gly ester, thioester, or jeffamine glycidyl amine crosslinker includes at least two functional groups.

5. The polymer film of claim 1 , wherein the at least one linkage is an ester, a thioester, a carbonate, a carbamate, or a combination thereof.

6. The polymer film of claim 1 , including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.

7. The polymer film of claim 1 , wherein the polymer film is substantially degraded within about 6 months of implantation.

8. The polymer film of claim 1 , wherein the polymer film is substantially degraded within about 1 month of implantation.

9. The polymer film of claim 1 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.

10. A polymer film comprising:
at least one monomer; and
at least one crosslinker selected from bis-glycidyl amino alcohol, bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate,

wherein a, b, c, d, e, and f are each independently 1-20.

11. The polymer film of claim 10 , wherein the at least one monomer includes at least one functional group selected from acrylate, acrylamide, methacrylate, or methacrylamide.

12. The polymer film of claim 10 , wherein the at least one monomer includes an ionizable functional group.

13. The polymer film of claim 12 , wherein the ionizable functional group is basic.

14. The polymer film of claim 12 , wherein the ionizable functional group is acidic.

15. The polymer film of claim 10 , including a second crosslinker including a linkage selected from an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.

16. The polymer film of claim 10 , wherein the polymer film is substantially degraded within about 6 months of implantation.

17. The polymer film of claim 10 , wherein the polymer film is substantially degraded within about 1 month of implantation.

18. The polymer film of claim 10 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.

19. The polymer film of claim 10 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Hincapie Gloria
• Harris Clayton
• Wu Yue

Classifications

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• C08F222/385

  Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• C08F220/56

  Acrylamide; Methacrylamide · CPC title