One-component-type dentinal tubule sealant

Patent metadata

Field	Value
Publication number	US-9962319-B2
Application number	US-201415024530-A
Country	US
Kind code	B2
Filing date	Sep 29, 2014
Priority date	Sep 30, 2013
Publication date	May 8, 2018
Grant date	May 8, 2018

Abstract

A dentinal tubule sealant including apatite particles (A) having an average particle diameter of 500 nm or less, a filler (B) having an average particle diameter of 1 to 10 μm, and a dispersant (C), wherein the weight ratio (A/B) of the apatite particles (A) to the filler (B) is 0.05 to 15, the dentinal tubule sealant contains 15 to 95 parts by weight of the dispersant (C) relative to 100 parts by weight in total of the apatite particles (A) and the filler (B), and the total amount of the apatite particles (A), the filler (B), and the dispersant (C) is 85 parts by weight or more relative to 100 parts by weight of the dentinal tubule sealant. There is thereby provided a dentinal tubule sealant excelling in dentinal tubule sealability immediately after treatment, durability of dentinal tubule sealing, ease of operation, and storage stability.

First claim

The invention claimed is:

1. A dentinal tubule sealant, comprising:
(A) apatite particles (A) having an average particle diameter of 500 nm or less;
(B) a filler (B) having an average particle diameter of 1 to 10 μm; and
(C) a dispersant (C),
wherein the dentinal tubule sealant comprises 0 to 20 parts by weight of water, relative to 100 parts by weight of the dentinal tubule sealant,
wherein:
a weight ratio (A/B) of the apatite particles (A) to the filler (B) is 0.05 to 15;
the dentinal tubule sealant comprises 15 to 95 parts by weight of the dispersant (C) relative to 100 parts by weight in total of the apatite particles (A) and the filler (B);
a total amount of the apatite particles (A), the filler (B), and the dispersant (C) is 85 parts by weight or more relative to 100 parts by weight of the dentinal tubule sealant;
the filler (B) is an inorganic filler (b) comprising a mixture of basic calcium phosphate particles (b1), poorly-soluble calcium phosphate particles (b2) and a phosphorus-free calcium compound (b3), wherein a Ca/P ratio of the sum of (b1), (b2) and (b3) is 1.7 to 2.8;
the basic calcium phosphate particles (b1) comprise at least one member selected from the group consisting of tetracalcium phosphate (Ca 4 (PO 4 ) 2 O) particles and apatite particles;
the poorly-soluble calcium phosphate particles (b2) comprise at least one member selected from the group consisting of anhydrous calcium monohydrogen phosphate (CaHPO 4 ) particles and tricalcium phosphate (Ca 3 (PO 4 ) 2 ) particles; and
the phosphorus-free calcium compound (b3) is at least one member selected from the group consisting of calcium hydroxide (Ca(OH) 2 ) and calcium carbonate (CaCO 3 ).

2. The dentinal tubule sealant according to claim 1 , wherein the inorganic filler (b) further comprises an inorganic filler (b4) other than (bp to (b3).

3. The dentinal tubule sealant according to claim 1 , wherein the dispersant (C) is water, a nonaqueous liquid, or both.

4. The dentinal tubule sealant according to claim 3 , wherein the dispersant (C) comprises at least one nonaqueous liquid selected from the group consisting of a polyether, a monohydric alcohol, and a polyhydric alcohol.

5. The dentinal tubule sealant according to claim 1 , wherein the basic calcium phosphate particles (b1) comprise tetracalcium phosphate (Ca 4 (PO 4 ) 2 O) particles.

6. The dentinal tubule sealant according to claim 1 , wherein the basic calcium phosphate particles (b1) comprise apatite particles.

7. The dentinal tubule sealant according to claim 1 , wherein the poorly-soluble calcium phosphate particles (b2) comprise anhydrous calcium monohydrogen phosphate (CaHPO 4 ) particles.

8. The dentinal tubule sealant according to claim 1 , wherein the poorly-soluble calcium phosphate particles (b2) comprise tricalcium phosphate (Ca 3 (PO 4 ) 2 ) particles.

9. The dentinal tubule sealant according to claim 1 , wherein the phosphorus-free calcium compound (b3) comprises calcium hydroxide (Ca(OH) 2 ).

10. The dentinal tubule sealant according to claim 1 , the phosphorus-free calcium compound (b3) comprises calcium carbonate (CaCO 3 ).

11. The dentinal tubule sealant according to claim 1 , which is a one-component-type dentinal tubule sealant.

12. The dentinal tubule sealant according to claim 2 , wherein the inorganic filler (b4) comprises at least one member selected from the group consisting of quartz, silica, alumina, zirconia, titania, silica-titania, silica-titania-barium oxide, silica-zirconia, silica-alumina, lanthanum glass, borosilicate glass, soda glass, barium glass, strontium glass, glass ceramics, aluminosilicate glass, barium boroaluminosilicate glass, strontium boroaluminosilicate glass, fluoroaluminosilicate glass, calcium fluoroaluminosilicate glass, strontium fluoroaluminosilicate glass, barium fluoroaluminosilicate glass, and strontium calcium fluoroaluminosilicate glass.

13. The dentinal tubule sealant according to claim 2 , wherein the inorganic filler (b4) comprises at least one member selected from the group consisting of barium glass, fluoroaluminosilicate glass, silica, and zirconia.

14. The dentinal tubule sealant according to claim 1 , wherein the dispersant (C) comprises at least one nonaqueous liquid selected from the group consisting of polyethylene glycol, polypropylene glycol, ethanol, methanol, glycerol, ethylene glycol, propylene glycol, and diglycerol.

15. The dentinal tubule sealant according to claim 1 , wherein the dispersant (C) comprises water.

16. The dentinal tubule sealant according to claim 1 , wherein the dispersant (C) comprises at least one member selected from the group consisting of glycerol and polyethylene glycol.

17. The dentinal tubule sealant according to claim 1 , which contains 15 to 95 parts by weight of the dispersant (C) relative to 100 parts by weight in total of the apatite particles (A) and the filler (B).

18. The dentinal tubule sealant according to claim 1 , wherein the total amount of the apatite particles (A), the filler (B), and the dispersant (C) is 85 parts by weight or more relative to 100 parts by weight of the dentinal tubule sealant.

19. A method of preparing the dentinal tubule sealant according to claim 1 , comprising combining (A), (B) and (C).

20. A method of sealing a dentinal tubule, comprising applying the dentinal tubule according to claim 1 to the dentin of teeth.

Assignees

• Kuraray Noritake Dental Inc

Inventors

• Ishihara Shumei
• Hatanaka Kenji

Classifications

• C04B2111/00836

  for medical or dental applications · CPC title

• C04B28/34

  containing cold phosphate binders · CPC title

• A61K6/80

  Preparations for artificial teeth, for filling teeth or for capping teeth · CPC title

• A61K6/20

  Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish · CPC title

• A61K6/838 Primary

  Phosphorus compounds, e.g. apatite · CPC title