Method for inhibiting dentinal hypersensitivity

Patent metadata

Field	Value
Publication number	US-9415068-B2
Application number	US-201313896994-A
Country	US
Kind code	B2
Filing date	May 17, 2013
Priority date	Mar 30, 2009
Publication date	Aug 16, 2016
Grant date	Aug 16, 2016

Abstract

A method for inhibiting dentinal hypersensitivity by applying a dentinal hypersensitivity inhibitor on a dentin surface. The dentinal hypersensitivity inhibitor contains at least one tetracalcium phosphate particle, an alkali metal salt of phosphoric acid, and at least one acidic calcium phosphate particle. The tetracalcium phosphate particle has an average particle diameter of 0.5 to 40 μm. The dentinal hypersensitivity inhibitor contains a blended amount of the tetracalcium phosphate particle of 5 to 55 parts by weight relative to 100 parts by weight of a whole amount of the dentinal hypersensitivity inhibitor and a blended amount of the alkali metal salt of phosphoric acid of 1 to 100 parts by weight relative to 100 parts by weight of the tetracalcium phosphate particle.

First claim

The invention claimed is:

1. A method for inhibiting dentinal hypersensitivity, the method comprising:
closing at least one dentinal tubule on a dentin surface by rubbing the dentin surface with a dentinal hypersensitivity inhibitor,
wherein the dentinal hypersensitivity inhibitor comprises at least one tetracalcium phosphate particle (A), an alkali metal salt of phosphoric acid (B), and at least one acidic calcium phosphate particle (C),
wherein the at least one tetracalcium phosphate particle (A) has an average particle diameter of 0.5 to 30 μm,
wherein the at least one acidic calcium phosphate particle (C) has an average particle diameter of 0.1 to 7 μm,
wherein the dentinal hypersensitivity inhibitor comprises a blended amount of the at least one tetracalcium phosphate particle (A) of 15 to 55 parts by weight relative to 100 parts by weight of a whole amount of the dentinal hypersensitivity inhibitor and a blended amount of the alkali metal salt of phosphoric acid (B) of 6.8 to 54.8 parts by weight relative to 100 parts by weight of the at least one tetracalcium phosphate particle (A), and
wherein a blending ratio of (A/C) of the at least one tetracalcium phosphate particle (A) to the at least one acidic calcium phosphate particle (C) is from 40/60 to 60/40 in a molar ratio.

2. The method of claim 1 , wherein the alkali metal salt of phosphoric acid (B) is at least one selected from the group consisting of disodium hydrogen phosphate and sodium dihydrogen phosphate.

3. The method of claim 1 , wherein the acidic calcium phosphate particle (C) is at least one member selected from the group consisting of a dicalcium phosphate anhydrous [CaHPO 4 ] particle, a monocalcium phosphate anhydrous [Ca(H 2 PO 4 ) 2 ] particle, a tricalcium phosphate [Ca 3 (PO 4 ) 2 ] particle, an amorphous calcium phosphate [Ca 3 (PO 4 ) 2 .xH 2 O] particle, a calcium dihydrogen pyrophosphate [CaH 2 P 2 O 7 ] particle, a dicalcium phosphate dihydrate [CaHPO 4 .2H 2 O] particle, and a monocalcium phosphate monohydrate [Ca(H 2 PO 4 ) 2 .H 2 O] particle.

4. The method of claim 1 , wherein the dentinal hypersensitivity inhibitor further comprises a fluorine compound (D).

5. The method of claim 4 , wherein the fluorine compound (D) is sodium fluoride.

6. The method of claim 1 , wherein an average particle diameter of the alkali metal salt of phosphoric acid (B) is 0.5 to 20 μm.

7. The method of claim 1 , wherein the dentinal hypersensitivity inhibitor further comprises at least one particle (E) of 0.002 to 2 μm in average particle diameter.

8. The method of claim 7 , wherein the at least one particle (E) comprises silica or at least one metal oxide.

9. The method of claim 1 , wherein when a suspension is prepared by adding 0.05 g of the dentinal hypersensitivity inhibitor into 200 g of pure water of 25° C., a free alkali metal ion concentration of the suspension at a time of 10 minutes after the adding is 0.2 to 100 mg/L.

Assignees

• Kuraray Noritake Dental Inc

Inventors

• Hashimoto Tadashi
• Sugiura Mariko
• Ishihara Shumei
• Kawashima Mitsunobu
• Okada Koichi

Classifications

• A61P25/02

  for peripheral neuropathies · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61K6/838

  Phosphorus compounds, e.g. apatite · CPC title

• A61K6/20

  Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish · CPC title

• A61K8/0241

  Containing particulates characterized by their shape and/or structure (see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes) · CPC title