Implant coated with net-shaped or island-shaped low-crystallized hydroxyapatite and method for coating same

Patent metadata

Field	Value
Publication number	US-9517187-B2
Application number	US-201013378029-A
Country	US
Kind code	B2
Filing date	May 18, 2010
Priority date	Jun 18, 2009
Publication date	Dec 13, 2016
Grant date	Dec 13, 2016

Abstract

The present disclosure relates to a method for coating a surface of a titanium implant with low crystalline hydroxyapatite having network- or island-like morphology and to an implant coated by such method.

First claim

The invention claimed is:

1. A method for coating a titanium or titanium alloy implant with hydroxyapatite, said method comprising:
pretreating a surface of a titanium or titanium alloy implant,
mixing a phosphate ion solution with a calcium ion solution to prepare a calcium phosphate solution, and
dipping and storing the titanium or titanium alloy implant in the calcium phosphate solution for 1 hour to provide a titanium or titanium alloy implant having a double surface with co-exposure of a network- or island-like coating of hydroxyapatite and the implant surface.

2. The method according to claim 1 , wherein the pretreatment step includes ultrasonic treatment of the titanium or titanium alloy implant in distilled water, a calcium ion solution, a phosphate ion solution or a calcium phosphate solution for 1 minute or more.

3. The method according to claim 2 , further comprising washing the titanium or titanium alloy implant with an acidic solution before the ultrasonic treatment of the implant.

4. The method according to claim 3 , wherein the acidic solution is a nitric acid solution.

5. The method according to claim 1 , wherein the phosphate ion solution is prepared by dissolving ammonium phosphates, sodium phosphates or potassium phosphates in distilled water.

6. The method according to claim 1 , wherein the calcium ion solution is prepared by dissolving calcium nitrate or calcium chloride in distilled water.

7. The method according to claim 1 or 2 , wherein a reaction temperature in the step of dipping and storing the titanium or titanium alloy implant in the calcium phosphate solution is in the range of 15° C. to 30° C.

8. The method according to claim 1 , wherein the pretreatment step is selected from the group consisting of an RBM (Resorbable Blasting Media) treatment, an SLA (Sand-blasted Large grit, and Acid etched) treatment, a heat treatment at 300° C. or higher, an anodization, and a heat treatment after an acid or base treatment.

9. The method according to claim 1 , wherein the calcium phosphate solution has a concentration of 1.0 mM to 10 mM.

10. The method according to claim 1 , wherein the pretreatment step includes ultrasonic treatment of the titanium or titanium alloy implant in distilled water, a calcium ion solution, a phosphate ion solution or a calcium phosphate solution for 1 minute, after RBM (Resorbable Blasting Media) treatment, an SLA (Sand-blasted Large grit, and Acid etched) treatment, a heat treatment at 300° C. or higher, an anodization, or a heat treatment after an acid or base treatment.

Assignees

• Ha Kyung Won
• Choi Gyu Ok
• Osstem Implant Co Ltd

Inventors

• Ha Kyung Won
• Choi Gyu Ok

Classifications

• C23C22/22

  containing alkaline earth metal cations · CPC title

• C23F1/26

  for etching refractory metals · CPC title

• A61K6/20

  Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish · CPC title

• A61K6/84

  comprising metals or alloys · CPC title

• A61K6/838

  Phosphorus compounds, e.g. apatite · CPC title