Formulations and materials with cationic polymers

Patent metadata

Field	Value
Publication number	US-2016184190-A1
Application number	US-201414908911-A
Country	US
Kind code	A1
Filing date	Jul 31, 2014
Priority date	Aug 2, 2013
Publication date	Jun 30, 2016
Grant date	—

Abstract

This invention provides fluid formulations and materials produced therefrom for repairing dental and bone defects, processes for the production of the fluid formulations and materials, and to uses of these formulations and materials. In particular, the invention provides the use cationic polymers such as polylysine in these formulations and materials, and the advantageous properties derived therefrom which include mechanical and antibacterial properties.

First claim

1 . A process for production of a material comprising the steps of:
i) providing a fluid formulation comprising (1) at least one compound capable of polymerisation and/or cross-linking, (2) optionally a filler, and (3) a cationic polymer; ii) optionally introducing said fluid formulation into a site of use; and iii) polymerising and/or cross-linking said compound, to form a solid polymer matrix comprising the cationic polymer.

2 . The process of claim 1 , wherein the cationic polymer comprises a monomeric subunit having a nitrogen-containing group.

3 . The process of claim 1 , wherein the cationic polymer is selected from the group consisting of polylysine, polyarginine, polyhistamine, chitosan, a polyamide, polyacrylamide, polyisopropylacrylamide, polyethylenimine and pre-polymerised methacryates.

4 . (canceled)

5 . The process of claim 1 , wherein the at least one compound capable of polymerisation and/or cross-linking comprises a polymerisable methacrylate moiety UDMA, PPGDMA, BISGMA, methylmethacrylate, acrylic acid, HEMA, TEGDMA or polyacid.

6 . The process of claim 1 , wherein the formulation further comprises one or more of the following additives: a polymerisation initiator; diluent monomers; hydroxyquinone; or an active agent.

7 . The process of claim 1 , wherein the fluid formulation comprises the filler, and the filler comprises an active agent selected from one or more of an antibacterial agent, chlorhexidine, cetyl pyridinium chloride, thymol, an antibiotic, gentamicin, tetracycline, oxycycline or minocycline.

8 . The process of claim 7 , wherein the filler comprises between about 2 and 10 wt % chlorhexidine.

9 . (canceled)

10 . The process of claim 1 , wherein the filler is present and comprises a reactive component, and the method further comprises:
iv) causing or allowing said filler to react with water to produce a solid filler material comprising the cationic polymer which is dispersed throughout the material.

11 . The process of claim 10 wherein the reactive component comprises at least one calcium-containing compound.

12 . The process of claim 11 wherein the calcium-containing compound is selected from the group consisting of: α or β tricalcium phosphate (TCP); dicalcium phosphate; dicalcium phosphate dihydrate (brushite); calcium dihydrogen phosphate; monocalcium phosphate monohydrate (MCPM); tetracalcium phosphate; and α, β or γ calcium pyrophosphate.

13 . (canceled)

14 . The process of claim 11 , wherein the reactive component is a mixture of β-TCP and MCPM, optionally in a 1:1 molar ratio, or a mixture of tristrontium phosphate and MCPM, optionally in a 1:1 molar ratio.

15 . (canceled)

16 . The process of claim 1 , wherein the filler is present and comprises glass powder or silane-treated glass powder.

17 . (canceled)

18 . The process of claim 1 , wherein the filler is present and comprises about 5 to 25 wt % glass fibres.

19 . The process of claim 1 , wherein the formulation comprises a polymerisation activator selected from NTGGMA or DMPT.

20 . The process of claim 1 , wherein the filler is present and comprises about 0.1-20 wt % polylysine and about 0-10 wt % chlorhexidine, and optionally about 0.5-10 wt % polylysine.

21 . The process of claim 1 , wherein the filler is present and comprises the cationic polymer.

22 . The process of claim 1 , wherein the cationic polymer is in a fluid phase of the fluid formulation.

23 . The process of claim 1 , wherein the material is a composite, a compomer, a glass ionomer cement, a resin-modified glass ionomer cement, a surface coating, cement or an adhesive.

24 - 31 . (canceled)

32 . A material for tooth or bone repair, comprising:
(1) a polymer matrix, and (2) a cationic polymer distributed in said matrix, wherein the material is preferably a composite, compomer, glass ionomer cement, resin modified glass ionomer cement, a surface coating, cement or adhesive.

33 . A material for tooth or bone repair obtained by the process of claim 1 , wherein the polymer matrix is formed by polymerisation or cross linking of the compound capable of polymerising and/or cross-linking.

34 . A material as claimed in claim 32 , wherein the material further comprises a solid filler, wherein the solid filler is brushite or hydroxyapatite.

35 . A method of tooth or bone repair, or of fixation of a dental or surgical implant into a cavity or location, which method comprises performing the process of claim 1 , wherein:
(i) the fluid formulation is introduced into the site of the tooth or bone damage or the cavity or location; (ii) polymerising and/or cross-linking said compound is performed by curing said formulation to form a material which is adhered to the damaged tooth or bone or the cavity or location.

36 . (canceled)

37 . The method according to claim 35 , wherein:
(i) the cationic polymer promotes water sorption of the material; (ii) the cationic polymer promotes formation of a bone or dentine-like layer on the material, and re-adsorbs on this layer; (iii) the material comprises an active agent and the cationic polymer promotes release of the active agent; (iv) the cationic polymer enhances conversion of the polymerising and/or cross-linking compound to a polymer matrix; or (v) any combination thereof.

38 - 51 . (canceled)

52 . A kit for producing a fluid formulation and/or a material for tooth or bone repair, comprising:
(a) at least one compound capable of polymerising and/or cross-linking to form a solid polymer matrix; (b) optionally a filler, optionally comprising a reactive component capable of reaction with water absorbed into the polymer matrix to produce a solid material; (c) a cationic polymer, optionally forming part of the filler; and (d) optionally written instructions for combining the compound capable of polymerising and/or cross-linking, cationic polymer and optional filler and curing them.

53 . (canceled)

Assignees

• Ucl Business Plc

Inventors

• Young Anne Margaret

Classifications

• A61K6/887

  Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61L27/46 Primary

  with phosphorus-containing inorganic fillers · CPC title

• A61K6/69

  Medicaments · CPC title

• A61K6/838

  Phosphorus compounds, e.g. apatite · CPC title

• A61K6/891 Primary

  Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title