Antigen-presenting platelets and methods of eliciting an immune response

Patent metadata

Field	Value
Publication number	US-9340773-B2
Application number	US-201214000959-A
Country	US
Kind code	B2
Filing date	Feb 22, 2012
Priority date	Feb 22, 2011
Publication date	May 17, 2016
Grant date	May 17, 2016

Abstract

Provided herein are methods of producing an antigen-presenting platelet. Also provided herein are methods of eliciting an immune response in a subject using the antigen-presenting platelets described herein. Also provided are methods of screening for an immune response elicited by an antigen-presenting platelet. Further provided are isolated populations of platelets that present a selected antigen produced by the methods described herein.

First claim

What is claimed is:

1. A method of eliciting an immune response in a subject, the method comprising:
a. providing antigen-presenting platelets, wherein the platelets present a selected antigen; and
b. administering to the subject the antigen-presenting platelets, wherein administration of the antigen-presenting platelets elicits an immune response in the subject, wherein the antigen-presenting platelets are of the same species as the subject.

2. The method of claim 1 , wherein the antigen-presenting platelets are administered to the subject at least two times.

3. The method of claim 2 , wherein the second administration of antigen-presenting platelets is at least five, six, seven, eight, nine, ten, eleven, twelve, thirteen, or fourteen days after the first administration.

4. The method of claim 1 , further comprising administering an adjuvant to the subject.

5. The method of claim 1 , wherein the antigen-presenting platelets are produced by platelets isolated from the same subject.

6. The method of claim 1 , wherein the antigen-presenting platelets are produced by platelets isolated from a different subject.

7. The method of claim 1 , wherein the method further comprises administering to the subject an antigen-presenting cell.

8. The method of claim 7 , wherein the antigen-presenting cell is a dendritic cell.

Assignees

• Morrell Craig
• Univ Rochester

Inventors

• Morrell Craig

Classifications

• A61K40/438

  Hemosporidia antigens, e.g. Plasmodium antigens · CPC title

• A61K40/42

  Cancer antigens · CPC title

• A61K40/10

  characterised by the cell type used · CPC title

• A61K2239/38

  characterised by the dose, timing or administration schedule · CPC title

• A61K2239/31

  characterized by the route of administration · CPC title