Biomedical patches with aligned fibers

Patent metadata

Field	Value
Publication number	US-10617512-B2
Application number	US-201916540548-A
Country	US
Kind code	B2
Filing date	Aug 14, 2019
Priority date	Jun 17, 2010
Publication date	Apr 14, 2020
Grant date	Apr 14, 2020

Abstract

A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

First claim

What is claimed is:

1. A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate, the multi-laminar electrospun nanofiber scaffold comprising:
a first layer formed by a first plurality of deposited electrospun polymeric fibers; and
a second layer formed by a second plurality of deposited electrospun polymeric fibers, wherein the second layer is combined with the first layer,
wherein at least a first portion of the multi-laminar electrospun nanofiber scaffold comprises a higher density of fibers than a second portion of the multi-laminar electrospun nanofiber scaffold, wherein the first portion comprises a higher tensile strength than the second portion,
wherein the multi-laminar electrospun nanofiber scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition,
wherein the multi-laminar electrospun nanofiber scaffold is configured to be applied to the tissue substrate containing the defect,
wherein the multi-laminar electrospun nanofiber scaffold comprises varying density to be sufficiently flexible to facilitate application of the multi-laminar electrospun nanofiber scaffold to uneven surfaces of the tissue substrate, and
wherein the multi-laminar electrospun nanofiber scaffold comprises varying density to be sufficiently flexible to enable movement of the multi-laminar electrospun nanofiber scaffold by the tissue substrate.

2. The multi-laminar electrospun nanofiber scaffold of claim 1 , wherein the first plurality of deposited electrospun polymeric fibers comprises polyglycolic acid.

3. The multi-laminar electrospun nanofiber scaffold of claim 1 , wherein the second plurality of deposited electrospun polymeric fibers comprises caprolactone.

4. The multi-laminar electrospun nanofiber scaffold of claim 1 , wherein at least one of the first plurality of deposited electrospun polymeric fibers and the second plurality of deposited electrospun polymeric fibers are radially aligned.

5. The multi-laminar electrospun nanofiber scaffold of claim 1 , wherein at least one of the first plurality of deposited electrospun polymeric fibers and the second plurality of deposited electrospun polymeric fibers are non-radially aligned.

6. The multi-laminar electrospun nanofiber scaffold of claim 1 , wherein at least one of the first plurality of deposited electrospun polymeric fibers and the second plurality of deposited electrospun polymeric fibers are randomly oriented.

7. The multi-laminar electrospun nanofiber scaffold of claim 1 , wherein the first plurality of deposited electrospun polymeric fibers and the second plurality of deposited electrospun polymeric fibers are non-radially aligned.

8. A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate, the multi-laminar electrospun nanofiber scaffold comprising:
a first layer formed by a first plurality of deposited electrospun polymeric fibers; and
a second layer formed by a second plurality of deposited electrospun polymeric fibers, wherein the second layer is combined with the first layer,
wherein at least a first portion of the multi-laminar electrospun nanofiber scaffold comprises a higher density of fibers than a second portion of the multi-laminar electrospun nanofiber scaffold, wherein the first portion comprises a higher tensile strength than the second portion,
wherein the first layer and the second layer are configured to separate via hydrolysis after at least one of a predetermined time or an environmental condition,
wherein the multi-laminar electrospun nanofiber scaffold is configured to be applied to the tissue substrate containing the defect,
wherein the multi-laminar electrospun nanofiber scaffold comprises varying density to be sufficiently flexible to facilitate application of the multi-laminar electrospun nanofiber scaffold to uneven surfaces of the tissue substrate, and
wherein the multi-laminar electrospun nanofiber scaffold comprises varying density to be sufficiently flexible to enable movement of the multi-laminar electrospun nanofiber scaffold by the tissue substrate.

9. The multi-laminar electrospun nanofiber scaffold of claim 8 , wherein the first plurality of deposited electrospun polymeric fibers comprises polyglycolic acid.

10. The multi-laminar electrospun nanofiber scaffold of claim 8 , wherein the second plurality of deposited electrospun polymeric fibers comprises caprolactone.

11. The multi-laminar electrospun nanofiber scaffold of claim 8 , wherein at least one of the first plurality of deposited electrospun polymeric fibers and the second plurality of deposited electrospun polymeric fibers are radially aligned.

12. The multi-laminar electrospun nanofiber scaffold of claim 8 , wherein at least one of the first plurality of deposited electrospun polymeric fibers and the second plurality of deposited electrospun polymeric fibers are non-radially aligned.

13. The multi-laminar electrospun nanofiber scaffold of claim 8 , wherein at least one of the first plurality of deposited electrospun polymeric fibers and the second plurality of deposited electrospun polymeric fibers are randomly oriented.

14. The multi-laminar electrospun nanofiber scaffold of claim 8 , wherein the first plurality of deposited electrospun polymeric fibers and the second plurality of deposited electrospun polymeric fibers are non-radially aligned.

15. A three-dimensional electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate, the three-dimensional electrospun nanofiber scaffold comprising:
a first layer formed by a first plurality of deposited electrospun polymeric fibers; and
a second layer formed by a second plurality of deposited electrospun polymeric fibers, wherein the second layer is combined with the first layer,
wherein at least a first portion of the three-dimensional electrospun nanofiber scaffold comprises a higher density of fibers than a second portion of the three-dimensional electrospun nanofiber scaffold,
wherein the first portion comprises a higher tensile strength than the second portion,
wherein the three-dimensional electrospun nanofiber scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition,
wherein the three-dimensional electrospun nanofiber scaffold is configured to be applied to the tissue substrate containing the defect,
wherein the three-dimensional electrospun nanofiber scaffold comprises varying density to be sufficiently flexible to facilitate application of the three-dimensional electrospun nanofiber scaffold to uneven surfaces of the tissue substrate, and
wherein the three-dimensional electrospun nanofiber scaffold comprises varying density to be sufficiently flexible to enable movement of the three-dimensional electrospun nanofiber scaffold by the tissue substrate.

16. The three-dimensional electrospun nanofiber scaffold of claim 15 , wherein the first plurality of deposited electrospun polymeric fibers comprises polyglycolic acid.

17. The three-dimensional electrospun nanofiber scaffold of claim 15 , wherein at least one of the first plurality of deposited electrospun polymeric fibers and the second plurality of deposited electrospun polymeric fibers are radially aligned.

18. The three-dimensional electrospun nanofiber scaffold of claim 15 , wherein at least one of the first plurality of deposited electrospun polymeric fibers and the second plurality of deposited electrospun polymeric fibers are non-radially aligned.

Assignees

• Univ Washington

Inventors

• Macewan Matthew R
• Xie Jingwei
• Ray Zack
• Xia Younan

Classifications

• D04H1/728

  by electro-spinning {(electro-spinning methods and apparatus D01D5/0007)} · CPC title

• D04H3/016

  characterised by the fineness · CPC title

• A61L15/42

  Use of materials characterised by their function or physical properties (liquid bandages A61L26/00) · CPC title

• C12M25/14

  Scaffolds; Matrices (in general C12N5/0068) · CPC title

• B29C48/142

  using force fields, e.g. gravity or electrical fields (B29C48/9165 takes precedence) · CPC title