Method of making biomedical patches with spatially arranged fibers

Patent metadata

Field	Value
Publication number	US-10124089-B2
Application number	US-201214429976-A
Country	US
Kind code	B2
Filing date	Sep 21, 2012
Priority date	Sep 21, 2012
Publication date	Nov 13, 2018
Grant date	Nov 13, 2018

Abstract

A system and methods for producing a structure including a plurality of fibers is provided. The system includes a polymer collector having a predefined pattern, wherein the collector is charged at a first polarity, and a spinneret configured to dispense a polymer, wherein the spinneret is charged at a second polarity substantially opposite the first polarity such that polymer dispensed from the spinneret forms a plurality of fibers on the predefined pattern of the fiber collector.

First claim

What is claimed is:

1. A method for producing a structure including a plurality of fibers, the method comprising:
providing a collector with a predefined pattern;
charging the collector with a first polarity;
providing a spinneret, the spinneret configured to dispense a polymer on the provided collector;
charging at least a portion of the spinneret to a second polarity substantially opposite at least a portion of the first; and
dispensing the polymer on the collector via a focusing device, such that at least a portion of the polymer forms the plurality of fibers defining the structure, wherein the structure has at least two densities formed by the plurality of fibers.

2. A method in accordance with claim 1 , further comprising applying at least one of a growth factor and a drug to the plurality of fibers.

3. A method in accordance with claim 1 , further comprising chemically treating the plurality of fibers.

4. A method in accordance with claim 1 , wherein providing the collector further comprises providing the collector including a plurality of features that are interconnected to form the predefined pattern.

5. A method in accordance with claim 4 , wherein providing the collector further comprise providing the collector including at least one surface positioned within the interconnected features.

6. A method in accordance with claim 1 , wherein providing the collector further comprises providing the collector such that the predefined pattern is configured to produce the structure with at least two fiber densities.

7. A method in accordance with claim 1 , wherein the focusing device is charged to the second polarity.

Assignees

• Univ Washington

Inventors

• Macewan Matthew R

Classifications

• A61L15/26 Primary

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)} · CPC title

• A61F13/02 Primary

  Adhesive bandages or dressings · CPC title

• D10B2509/00

  Medical; Hygiene · CPC title

• D01D5/0076

  characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid (D01D5/0046 takes precedence) · CPC title

• A61L2430/32

  for nerve reconstruction · CPC title