Polymer particles

Patent metadata

Field	Value
Publication number	US-10519264-B2
Application number	US-201816147225-A
Country	US
Kind code	B2
Filing date	Sep 28, 2018
Priority date	Nov 8, 2013
Publication date	Dec 31, 2019
Grant date	Dec 31, 2019

Abstract

Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.

First claim

We claim:

1. A polymer particle comprising:
poly(ethylene glycol) diacrylamide, glycerol monomethacrylate, and amino ethyl methacrylate;
wherein the polymer particle is spherical and has a diameter less than about 1,200 μm.

2. The polymer particle of claim 1 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.

3. The polymer particle of claim 1 , further comprising N,N-methylenebisacrylamide.

4. The polymer particle of claim 1 , wherein the N,N-methylenebisacrylamide is at a concentration of about 1% w/w.

5. The polymer particle of claim 1 , wherein the poly(ethylene glycol) diacrylamide is at a concentration of about 28% w/w.

6. The polymer particle of claim 1 , wherein the glycerol monomethacrylate is present at a concentration of about 68% w/w.

7. The polymer particle of claim 1 , wherein the amino ethyl methacrylate at a concentration of about 3% w/w.

8. The polymer particle of claim 1 , wherein the poly(ethylene glycol) diacrylamide is poly(ethylene glycol) diacrylamide 10,000.

9. The particle of claim 1 , further comprising a drug.

10. A polymer particle comprising:
poly(ethylene glycol) diacrylamide, 3-sulfopropyl acrylate, and amino propyl methacrylamide,
wherein the polymer particle is spherical and has a diameter less than about 1,200 μm.

11. The polymer particle of claim 10 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.

12. The polymer particle of claim 10 , wherein the poly(ethylene glycol) diacrylamide is at a concentration of about 40% w/w.

13. The polymer particle of claim 10 , wherein the at least one monomer is 3-sulfopropyl acrylate at a concentration of about 59% w/w.

14. The polymer particle of claim 10 , wherein the amino propyl methacrylamide is at a concentration of about 1% w/w.

15. The polymer particle of claim 10 , wherein the poly(ethylene glycol) diacrylamide is poly(ethylene glycol) diacrylamide 10,000.

16. The particle of claim 11 , further comprising a drug.

17. A kit comprising:
a plurality of polymer particles in a container,
wherein the plurality of polymer particles comprise poly(ethylene glycol) diacrylamide, glycerol monomethacrylate, and amino ethyl methacrylate;
wherein the plurality of polymer particles are spherical and have a diameter less than about 1,200 μm.

18. The kit of claim 17 , wherein the container is a vial or a syringe.

19. A kit comprising:
a plurality of polymer particles in a container,
wherein the plurality of polymer particles comprise poly(ethylene glycol) diacrylamide, 3-sulfopropyl acrylate, and amino propyl methacrylamide;
wherein the plurality of polymer particles are spherical and have a diameter less than about 1,200 μm.

20. The kit of claim 19 , wherein the container is a vial or a syringe.

Assignees

• Terumo Corp

Inventors

• Plotkin Steve
• Cruise Gregory M
• Keeley Edward Michael
• Yu Renee
• Harris Clayton

Classifications

• C08F16/06

  Polyvinyl alcohol {; Vinyl alcohol} · CPC title

• C08F20/56

  Acrylamide; Methacrylamide · CPC title

• C08F20/38

  Esters containing sulfur · CPC title

• C08F20/28

  containing no aromatic rings in the alcohol moiety · CPC title

• C08F220/282

  and containing two or more oxygen atoms · CPC title