Polymer films

Patent metadata

Field	Value
Publication number	US-2016311990-A1
Application number	US-201615199633-A
Country	US
Kind code	A1
Filing date	Jun 30, 2016
Priority date	Sep 19, 2013
Publication date	Oct 27, 2016
Grant date	—

Abstract

Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.

First claim

We claim:

1 . A polymer film comprising:
at least one monomer including at least one functional group selected from acrylate, acrylamide, methacrylate, or methacrylamide; and at least one crosslinker including at least one linkage susceptible to degradation through hydrolysis or enzymatic action.

2 . The polymer film of claim 1 , wherein the at least one monomer includes an ionizable functional group.

3 . The polymer film of claim 2 , wherein the ionizable functional group is basic or acidic.

4 . The polymer film of claim 1 , wherein the at least one crosslinker includes at least two functional groups.

5 . The polymer film of claim 1 , wherein the at least one linkage is an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenase, a peptide cleavable by matrix elastase, a peptide cleavable by matrix cathepsin, or a combination thereof.

6 . The polymer film of claim 1 , including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.

7 . The polymer film of claim 1 , wherein the polymer film is substantially degraded within about 6 months of implantation.

8 . The polymer film of claim 1 , wherein the polymer film is substantially degraded within about 1 month of implantation.

9 . The polymer film of claim 1 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.

10 . The polymer film of claim 1 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.

11 . A polymer film comprising:
at least one monomer; and at least one crosslinker selected from bis-glycidyl amino alcohol, bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate,

wherein a, b, c, d, e, and f are each independently 1-20.

12 . The polymer film of claim 11 , wherein the at least one monomer includes at least one functional group selected from acrylate, acrylamide, methacrylate, or methacrylamide.

13 . The polymer film of claim 11 , wherein the at least one monomer includes an ionizable functional group.

14 . The polymer film of claim 13 , wherein the ionizable functional group is basic.

15 . The polymer film of claim 13 , wherein the ionizable functional group is acidic.

16 . The polymer film of claim 11 , including a second crosslinker including a linkage selected from an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.

17 . The polymer film of claim 11 , wherein the polymer film is substantially degraded within about 6 months of implantation.

18 . The polymer film of claim 11 , wherein the polymer film is substantially degraded within about 1 month of implantation.

19 . The polymer film of claim 11 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.

20 . The polymer film of claim 11 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Hincapie Gloria
• Harris Clayton
• Wu Yue

Classifications

• C08J2333/14

  of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title

• A61L31/048

  obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence) · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• Y10T428/21

  Circular sheet or circular blank · CPC title