Use of PEO-PBO block copolymers in ophthalmic compositions

Patent metadata

Field	Value
Publication number	US-9574160-B2
Application number	US-94761410-A
Country	US
Kind code	B2
Filing date	Nov 16, 2010
Priority date	Dec 11, 2006
Publication date	Feb 21, 2017
Grant date	Feb 21, 2017

Abstract

The use of poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses. Such compounds are also useful for cleaning purposes. The use of the compounds as surfactants in various types of compositions for treating contact lenses therefore represents a preferred embodiment of the present invention.

First claim

We claim:

1. A method of treating a contact lens to modify the surface characteristics of the lens or clean the lens, which comprises applying to a silicone hydrogel contact lens an ophthalmic composition comprising 0.01 to about 1 weight/volume percent of at least one poly(oxyethylene)-poly(oxybutylene) block copolymer wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer is of the formula (EO)m(BO)n, wherein m is an integer having an average value of 20 to 45 and n is an integer having an average value of 5 to 14 and m is greater than n, having a molecular weight in the range of 500 to 100,000 Daltons and an ophthalmically acceptable vehicle therefor.

2. A method according to claim 1 , wherein the ratio of m to n is in the range of about 2:1 to about 6:1.

3. A method according to claim 2 , wherein the ratio of m to n is in the range of about 3:1 to about 6:1.

4. A method according to claim 3 , wherein the average value of m is 45 and the average value of n is 10.

5. A method according to claim 1 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer has a molecular weight in the range of 1,000 to 50,000 Daltons.

6. A method according to claim 5 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer has a molecular weight in the range of 2,000 to 10,000 Daltons.

7. A method according claim 1 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer is of the formula

wherein R is selected from the group consisting of hydrogen, methyl, ethyl, propyl and butyl; m is an integer having an average value of 20 to 45; and n is an integer having an average value of 5 to 14.

8. A method according to claim 7 , wherein R is methyl; m has an average value of 45; and n has an average value of 10.

9. A method according to claim 1 , further comprising an effective amount of a poly(oxyethylene)-poly(oxypropylene) block copolymer.

10. A method according to claim 9 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer comprises poloxamine 1304.

11. A method according to claim 1 , wherein the composition is a sterile aqueous solution for treating a contact lens, said solution having an osmolality of 200 to 400 milliosmoles/kilogram.

12. A method according to claim 11 , further comprising an ophthalmically acceptable antimicrobial agent in an amount effective to disinfect a contact lens.

13. A method according to claim 12 , wherein said antimicrobial agent comprises polyquatemium-1.

14. A method according to claim 1 , wherein the block copolymer concentration is 0.05% to 0.5% w/v.

15. A method according to claim 14 , wherein the block copolymer concentration is 0.1% to 0.2% w/v.

16. A method according to claim 15 , wherein the block copolymer concentration is 0.1% w/v.

17. A method according to claim 7 , wherein R is methyl; m has an average value of 45; and n has an average value of 14.

18. A method according to claim 7 , wherein R is methyl; m has an average value of 20; and n has an average value of 5.

Assignees

• Ketelson Howard Allen
• Mcqueen Nathaniel D
• Alcon Res Ltd

Inventors

• Ketelson Howard Allen
• Mcqueen Nathaniel D

Classifications

• A61P27/02

  Ophthalmic agents · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• C11D1/008

  Polymeric surface-active agents · CPC title

• C11D3/3707

  Polyethers, e.g. polyalkyleneoxides · CPC title

• B65D81/22

  in moist conditions or immersed in liquids · CPC title