Use of PBO-PEO-PBO block copolymers in ophthalmic compositions

Patent metadata

Field	Value
Publication number	US-9521842-B2
Application number	US-201514627422-A
Country	US
Kind code	B2
Filing date	Feb 20, 2015
Priority date	Jun 2, 2010
Publication date	Dec 20, 2016
Grant date	Dec 20, 2016

Abstract

The use of poly(oxybutylene)-poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses, but do not induce foaming when used in conjunction with a peroxide-based contact lens disinfection regimen. Such compounds may also be useful for cleaning purposes. The use of the compounds as surfactants in peroxide-based compositions for disinfecting contact lenses therefore represents a preferred embodiment of the present invention.

First claim

What is claimed is:

1. An ophthalmic composition for disinfecting contact lenses comprising an effective amount of at least one poly(oxybutylene)-poly(oxyethylene)-poly(oxybutylene) block copolymer of the formula (BO)n(EO)m(BO)n, wherein m is an integer having an average value of 9 to 182 and n is an integer having an average value of 3 to 21, having a molecular weight in the range of 500 to 12,000 Daltons and a concentration of peroxide of about 3% or more and an ophthalmically acceptable vehicle therefor, wherein the composition does not foam excessively upon neutralization with a metal catalyst.

2. A composition according claim 1 , wherein the poly(oxybutylene)-poly(oxyethylene)-poly(oxybutylene) block copolymer is of the formula

wherein R is independently selected from the group consisting of hydrogen, methyl, ethyl, propyl and butyl.

3. A composition according to claim 1 , further comprising an effective amount of a poly(oxyethylene)-poly(oxypropylene) block copolymer.

4. A composition according to claim 3 , wherein the poly(oxyethylene)-poly(oxypropylene) block copolymer is of the formula

5. A composition according to claim 1 , wherein the solution contains said block copolymer at a concentration of 0.001 to 1% w/v.

Assignees

• Alcon Res Ltd

Inventors

• Davis James W
• Ketelson Howard Allen

Classifications

• C11D3/48

  Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions · CPC title

• C11D3/3947

  Liquid compositions · CPC title

• C11D3/0078

  Compositions for cleaning contact lenses, spectacles or lenses · CPC title

• A01N59/00

  Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds · CPC title

• A61L12/142

  Polymeric biguanides · CPC title