Ophthalmic compositions comprising polyether substituted polymers

Patent metadata

Field	Value
Publication number	US-9511089-B2
Application number	US-201615044325-A
Country	US
Kind code	B2
Filing date	Feb 16, 2016
Priority date	Nov 22, 2004
Publication date	Dec 6, 2016
Grant date	Dec 6, 2016

Abstract

The present invention relates to ophthalmic solutions and devices comprising at least one water soluble polymer having a molecular weight of at least about 500,000 Daltons and comprising linear or branched polyether pendant groups having a molecular weight of at least about 300.

First claim

We claim:

1. An ophthalmic solution comprising at least one water soluble polymer having a molecular weight of at least about 500,000 Daltons and comprising linear or branched polyether pendant groups having a molecular weight of at least about 300; wherein said polyether pendant groups are derived from monomers of the Formula I
A-[(CZ p H q ) y —O] n —CH m —X 3-m

wherein n is greater than 7; Z is a C 1 -C 6 substituted or unsubstituted alkyl group, q is 0, 1 or 2 and p is 2-q, y is 2 to 4, m is 1 or 2; A is any free radical polymerizable group and X is a substituent independently selected from the group consisting of H, hydroxyl, unsubstituted straight or branched alkyl groups, substituted straight or branched alkyl groups, substituted and un substituted amines, substituted and un substituted amides, mercaptans, ethers and esters.

2. The solution of claim 1 wherein X is selected from substituted or unsubstituted straight or branched C1-16 alkyl groups.

3. The solution of claim 1 wherein X is selected from is selected from substituted or unsubstituted straight or branched C1-12 alkyl groups.

4. The solution of claim 2 wherein said alkyl group is substituted with a group selected from the group consisting of carboxylic acids, esters, acyl halides, amines, amides, ketones, aldehydes, halides, sulfides, mercaptans, quartenary ammonium salts and combinations thereof.

5. The solution of claim 1 wherein n is an integer of between 7 to 50.

6. The solution of claim 1 wherein said polymer comprises at least about 20% of backbone units have a pendant group bound thereto.

7. The solution of claim 1 wherein at least about 20% of said pendant groups are polyether pendant groups of Formula I.

8. The solution of claim 1 wherein said pendant groups further comprise at least one second pendant group selected from the group consisting of silicones, sugars, carbohydrates, polyethers, amides, lactams, sulfonic acids, sulfonates, amines, hydroxyls, ethers, esters, aldehydes, ketones, amino acids, methacrylated long chain hydrocarbons, polymerizable ionic compounds, reactive latent compounds which may be converted to ionic groups after the water soluble polymer is polymerized and combinations thereof.

9. The solution of claim 1 wherein said pendant groups further comprise at least one second pendant group selected from the group consisting of amides, lactams, glycosylated materials, polymerizable ionic compounds and combinations thereof.

10. The solution of claim 1 wherein said pendant groups further comprise at least one second pendant group selected from the group consisting lauryl methacrylate, butyl methacrylate, isopropyl methacrylate, methyl methacrylate, phenyl methacrylate, hydroxyethyl methacrylate, methacrylic acid, glycerol monomethacrylate, hydroxyethyl methacrylamide, 2-(-4-morpholinyl)ethyl methacrylate, morpholinyl methacrylamide, 2-(N,N-dimethylamino)ethyl methacrylate, dimethylacrylamide, N-vinyl pyrrolidone, N-vinyl-N-methylacetamide, styrene sulfonate, sodium 2-acrylamido-2-methyl-1-propanesulfonate, sulfopropylacrylamide and combinations thereof.

11. The solution of claim 1 , wherein said solution is a contact lens packing, storing or cleaning solution.

12. The solution of claim 1 , wherein said solution may be directly instilled into the eye.

13. The solution of claim 2 further comprising additional components selected from the group consisting of tonicity adjusting agents, viscosity adjusting agents, antimicrobial agents, polyelectrolytes and mixtures thereof.

14. The solution of claim 1 wherein n is an integer of between 7 to 50.

15. The solution of claim 1 wherein n is an integer of between 7 to 40.

16. The solution of claim 1 wherein said polymer comprises at least about 30% of backbone units have a pendant group bound thereto.

17. The solution of claim 1 wherein at least about 60% of said pendant groups are polyether pendant groups of Formula I.

18. The solution of claim 1 wherein at least about 75% of said pendant groups are polyether pendant groups of Formula I.

Assignees

• Johnson & Johnson Vision Care

Inventors

• Molock Frank
• Lorenz Katherine Osborn
• Mahadevan Shivkumar

Classifications

• A61P27/04

  Artificial tears; Irrigation solutions · CPC title

• G02B1/041

  Lenses · CPC title

• G02B1/043

  Contact lenses · CPC title

• C11D3/0078

  Compositions for cleaning contact lenses, spectacles or lenses · CPC title

• A61K31/765 Primary

  Polymers containing oxygen · CPC title