Magnetic resonance imaging contrast agents comprising zinc-containing magnetic metal oxide nanoparticles

Patent metadata

Field	Value
Publication number	US-9375495-B2
Application number	US-52748208-A
Country	US
Kind code	B2
Filing date	Apr 11, 2008
Priority date	Apr 12, 2007
Publication date	Jun 28, 2016
Grant date	Jun 28, 2016

Abstract

The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of “zinc-containing metal oxide nanoparticle—biologically/chemically active material” in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.

First claim

The invention claimed is:

1. An MRI contrast agent comprising zinc-containing metal oxide nanoparticles have a chemical formula of:
(a) Zn x Fe 3-x O 4 , wherein x=0.1-0.4,
wherein the dispersibility of the zinc-containing metal oxide nanoparticles to water is in the range of 1 μg/ml to 500 mg/ml, and the hydrodynamic diameter of the nanoparticles that are dispersed in water is in the range of 1 nm to 500 μm; wherein the zinc-containing metal oxide nanoparticle itself is dispersed in water, or the zinc-containing metal oxide nanoparticle is coated with water-soluble multi-functional group ligands to be dispersed in an aqueous solution; wherein the zinc-containing metal oxide nanoparticles have a saturation magnetization of 100 emu/g or more (magnetic atom), wherein the zinc-containing metal oxide nanoparticles are prepared by a method comprising synthesizing water-insoluble, zinc-containing nanoparticles in organic solvents, and wherein the zinc-containing metal oxide nanoparticles comprise zinc incorporated into a tetrahedron interstitial hole.

2. The MRI contrast agent as set forth in claim 1 , wherein x=0.2-0.4.

3. The MRI contrast agent as set forth in claim 1 , wherein x=0.4.

4. An MRI contrast agent comprising zinc-containing metal oxide nanoparticles have a chemical formula of:
Mn 1-x Zn x Fe 2 O 4 ; wherein x=0.1-0.4,
wherein the dispersibility of the zinc-containing metal oxide nanoparticles to water is in the range of 1 μg/ml to 500 mg/ml, and the hydrodynamic diameter of the nanoparticles that are dispersed in water is in the range of 1 nm to 500 μm; wherein the zinc-containing metal oxide nanoparticle itself is dispersed in water, or the zinc-containing metal oxide nanoparticle is coated with water-soluble multi-functional group ligands to be dispersed in an aqueous solution; wherein the zinc-containing metal oxide nanoparticles have a saturation magnetization of 100 emu/g or more (magnetic atom), wherein the zinc-containing metal oxide nanoparticles are prepared by a method comprising synthesizing water-insoluble, zinc-containing nanoparticles in organic solvents, and wherein the zinc-containing metal oxide nanoparticles comprise zinc incorporated into a tetrahedron interstitial hole.

5. The MRI contrast agent as set forth in claim 4 , wherein x=0.2-0.4.

Assignees

• Cheon Jinwoo
• Jun Young-Wook
• Jang Jung-Tak
• Univ Yonsei Iacf

Inventors

• Cheon Jinwoo
• Jun Young-Wook
• Jang Jung-Tak

Classifications

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• A61K49/1866

  the nanoparticle having a (super)(para)magnetic core coated or functionalised with a peptide, e.g. protein, polyamino acid · CPC title

• C01G49/0063

  containing zinc · CPC title

• Y10S977/93

  MRI contrast agent · CPC title

• A61K49/1863

  the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch · CPC title