Magnetic nanostructures as theranostic agents

Patent metadata

Field	Value
Publication number	US-9801952-B2
Application number	US-201514817710-A
Country	US
Kind code	B2
Filing date	Aug 4, 2015
Priority date	Oct 30, 2009
Publication date	Oct 31, 2017
Grant date	Oct 31, 2017

Abstract

The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer's disease and related diseases and conditions.

First claim

What is claimed is:

1. A method, comprising
a) administering a magnetic nanostructure comprising i) a magnetic nanostructure coated with a non-magnetic coating; and ii) a targeting agent, wherein said targeting agent targets said nanostructure to a Medulloblastoma cell of a subject;
b) detecting the presence of said cancer cell in said subject by identifying said magnetic nanostructure; and
c) destroying said cancer cell by exposing said magnetic nanostructure to a radio frequency that causes said magnetic nanostructure to generate heat.

2. The method of claim 1 , wherein said identifying said magnetic nanostructure comprises the use of magnetic resonance imaging.

3. The method of claim 1 , wherein said targeting agent is an antibody.

4. The method of claim 1 , wherein said magnetic nanostructure is present in a stable suspension.

5. A method, comprising
a) administering a magnetic nanostructure comprising i) a magnetic nanostructure coated with a non-magnetic coating; and ii) a targeting agent, wherein said targeting agent targets said nanostructure to a Medulloblastoma cell to a subject; and
b) detecting the presence of said cancer cell in said subject by identifying said magnetic nanostructure.

6. The method of claim 5 , further comprising the step of destroying said cancer cell by exposing said magnetic nanostructure to a radio frequency that causes said magnetic nanostructure to generate heat.

7. The method of claim 5 , wherein said identifying said magnetic nanostructure comprises the use of magnetic resonance imaging.

8. The method of claim 5 , wherein said targeting agent is an antibody.

9. The method of claim 5 , wherein said magnetic nanostructure is present in a stable suspension.

Assignees

• Univ Northwestern

Inventors

• Dravid Vinayak P

Classifications

• A61K47/6923 Primary

  the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb · CPC title

• A61K47/6865

  the tumour determinant being from skin, nerves or brain cancer cell · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• A61K49/186

  the organic macromolecular compound being polyethyleneglycol [PEG] · CPC title

• A61K49/1833

  having a (super)(para)magnetic core coated or functionalised with a small organic molecule (oligomeric, polymeric, dendrimeric A61K49/1851) · CPC title