Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same

Patent metadata

Field	Value
Publication number	US-10016499-B2
Application number	US-201615098063-A
Country	US
Kind code	B2
Filing date	Apr 13, 2016
Priority date	Mar 15, 2011
Publication date	Jul 10, 2018
Grant date	Jul 10, 2018

Abstract

The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.

First claim

We claim:

1. A method for treating a bacterial infection comprising administering to a patient infected with bacteria one or more nanoparticles, comprising:
(a) a metallic core having a length along each axis of from 1 to 100 nanometers; and
(b) a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, wherein one or more antibodies is bound to the coating, optionally further comprising polyethylene glycol, functionalized polyethylene glycol, or a mixture thereof bound to the coating, wherein the metallic core consists essentially of gold and wherein the antibody is an anti-bacterial surface antibody, wherein the anti-bacterial surface antibody is an anti-lipoteichoic acid antibody or an anti-endotoxin antibody, wherein lipoteichoic acid or endotoxin are present on the bacterial surface, wherein the coating of the one or more nanoparticles further comprises silver; and
further comprising the step of exposing the nanoparticles to light, whereby the one or more nanoparticles target the bacteria and the bacterial infection is effectively treated.

Assignees

• Univ Northwestern

Inventors

• Messersmith Phillip B
• Black Kvar C L
• Yi Ji
• Rivera Jose G

Classifications

• A61K31/69

  Boron compounds · CPC title

• G01N33/587

  Nanoparticles · CPC title

• A61K47/6923

  the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb · CPC title

• A61K9/1611

  Inorganic compounds · CPC title

• G01N21/554

  detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance · CPC title