Method of vital pulp therapy using bioactive composites

Patent metadata

Field	Value
Publication number	US-2026090960-A1
Application number	US-202418901829-A
Country	US
Kind code	A1
Filing date	Sep 30, 2024
Priority date	Sep 30, 2024
Publication date	Apr 2, 2026
Grant date	—

Abstract

A method of vital pulp therapy with a bioactive capping material. The method includes drilling into a pulp of a tooth having decay to form a hole, then excavating infected pulp from the hole. The bioactive capping material is prepared by mixing glass ionomer cement (GIC) and potassium nitrate (KNO 3 ) with a solvent. The method further includes covering healthy pulp in the tooth with the bioactive capping material and curing the bioactive capping material to form a cured capping material. The bioactive capping material includes KNO 3 in an amount of 1 to 10 percent by weight (wt. %) based on the weight of the capping material.

First claim

1 . A method of vital pulp therapy, comprising:
drilling into a pulp of a tooth to form a hole, then excavating infected pulp from the hole, wherein the tooth has a cavity breaching at least a surface of the pulp and is under lipopolysaccharide (LPS) stimulation during the drilling; mixing a glass ionomer cement (GIC) and potassium nitrate (KNO 3 ) with a solvent to form a bioactive capping material; and covering remaining healthy pulp in the hole of the tooth with the bioactive capping material and curing the bioactive capping material to form a cured capping material, wherein the KNO 3 is present in the bioactive capping material in an amount of 1 to 10 wt. % based on the weight of the bioactive capping material, and wherein after the curing, the patient has an IL-6 secretion that is 40 to 75% less than the IL-6 secretion after curing with a substantially identical method using the same bioactive capping material without the KNO 3 .

2 . The method of claim 1 , wherein a ratio of the solvent to a combined amount of GIC and KNO 3 is 1:3 to 3:1.

3 . The method of claim 1 , wherein the solvent is selected from the group consisting of water, ethanol, methanol, and acetone.

4 . The method of claim 1 , wherein the solvent is water.

5 . The method of claim 1 , wherein the cured capping material has a compressive strength of at least 450 N/cm 2 .

6 . The method of claim 1 , wherein the cured capping material has a microhardness of no more than 40 HV.

7 . The method of claim 1 , wherein the KNO 3 is present in an amount of 5 to 10 wt. % based on the weight of the capping material.

8 . The method of claim 1 , wherein the bioactive capping material has a pH of 6 to 7.

9 . The method of claim 1 , wherein the cured capping material has a compressive strength of at least 500 N/cm 2 .

10 . The method of claim 1 , wherein the cured capping material has a microhardness of no more than 35 HV.

11 . The method of claim 1 , wherein the bioactive capping material has a pH of 6.5.

12 . A method of treating inflammation near a tooth comprising:
drilling into a pulp of a tooth of a patient to form a hole, then excavating infected pulp from the hole, wherein the tooth has a cavity breaching at least a surface of the pulp; and administering a bioactive dental composite comprising a glass ionomer cement (GIC) and potassium nitrate to at least one surface of remaining healthy pulp of the tooth of a patient, wherein the potassium nitrate is present in an amount of 1 to 10 wt. % based on the weight of the dental composite, and wherein the dental composite promotes the release of a regenerative marker and inhibits the release of an inflammatory marker.

13 . The method of claim 12 , wherein the regenerative marker has a release level of at least 40 pg/mL.

14 . The method of claim 12 , wherein the regenerative marker is at least one selected from the group consisting of growth differentiation factor (GDF), inhibin A (INHA), myostatin (MSTN), and transforming growth factor (TGF-β).

15 . The method of claim 12 , wherein the inflammatory marker has a release level of at least 25 pg/mL.

16 . The method of claim 12 , wherein the inflammatory marker is at least one selected from the group consisting of C-reactive protein (CRP), serum amyloid A, procalcitonin, cytokines, TNFα, and interleukins 6 (IL-6).

17 . The method of claim 12 , wherein the bioactive dental composite releases at least one of nitrate, potassium, and fluoride on the surface of the tooth.

18 . The method of claim 12 , wherein the bioactive dental composite has an average potassium release level of at least 1000 ppm.

19 . The method of claim 12 , wherein the bioactive dental composite has an average nitrate release level of at least 50 ppm and an average fluoride release level of at least 4 ppm.

20 . The method of claim 1 , wherein LPS stimulation comprises injecting a lipopolysaccharide into an area surrounding the tooth to activate an immune response and induce inflammatory cytokine production.

Assignees

• Univ Imam Abdulrahman Bin Faisal

Inventors

• Algharni Mohammed
• Omar Omar
• Dahlawi Fatimah
• Alhumaid Jehan

Classifications

• A61K6/84

  comprising metals or alloys · CPC title

• A61K31/739

  Lipopolysaccharides · CPC title

• A61K6/849 Primary

  comprising inorganic cements · CPC title