Methods of treatment of the dental pulp and filling root canals using water-based material

Patent metadata

Field	Value
Publication number	US-9925125-B2
Application number	US-201514920544-A
Country	US
Kind code	B2
Filing date	Oct 22, 2015
Priority date	Feb 9, 2007
Publication date	Mar 27, 2018
Grant date	Mar 27, 2018

Abstract

A dental composition comprising: a) about 1 to about 80% by weight of particulate material including: (i) calcium silicate, calcium aluminate, tetracalcium aluminoferrite, calcium phosphate, calcium sulfate, silica, alumina, calcium oxide, calcium hydroxide, or mixtures thereof; wherein the particulate material has an average particle size of less than 40 microns; and b) about 1 to about 50% by weight liquid carrier including: (i) water-soluble polymer, and (ii) water.

First claim

What is claimed is:

1. A dental composition comprising:
a) about 1 to about 80% by weight of particulate material including:
(i) about 20 to about 80 wt. % tricalcium silicate;
about 20 to about 50 wt. % dicalcium silicate;
about 1 to about 20 wt. % tricalcium aluminate,
about 1 to about 20 wt. % tetracalcium aluminoferrite;
about 1 to about 15 wt. % of at least one of the following selected from the group consisting of calcium phosphate, calcium sulfate, silica, alumina, calcium oxide, calcium hydroxide, and mixtures thereof; and
about 1 to about 50 wt. % radiopaque component;

wherein the particulate material has an average particle size in the range of about 1 μm to about 40 μm and has a surface area in the range of 0.5 to 3.0 m 2 /q; and

b) about 1 to about 50% by weight liquid carrier including:
(i) water-soluble polymer; and
(ii) water;

wherein a ratio of the particulate material to the liquid carrier ranges from 1:1 to 2.5:1.

2. The composition of claim 1 , wherein the water-soluble polymer is selected from the group consisting of polyvinyl alcohols, polyvinyl-pyrrolidone (PVP), partially hydrolyzed polyvinyl acetates, (PVAc), polyacrylic acid (PAA), and polymethacrylic acid (PMA), hyaluronic acid, water-soluble poly-saccharides, poly amino-acids, and copolymers and mixtures thereof.

3. The composition of claim 1 , further comprising about 1 to about 30% by weight of hydroxyapatite.

4. The composition of claim 1 , wherein the radiopaque component is selected from the group consisting of bismuth oxide, barium sulfate, tantalum oxide, cerium oxide, tin oxide, zirconium oxide compounds and radiopaque glasses containing tantalum, barium and strontium, and mixtures thereof.

5. The composition of claim 1 , wherein the particulate material has an average particle size in the range of about 1 μm to about 15 μm.

6. The composition of claim 1 , further comprising anti-bacterial and/or anti-microbial agents.

7. The composition of claim 6 , wherein the anti-microbial agent includes chlorhexidine gluconate.

8. A method of treating a root canal in a tooth, comprising the steps of:
a) preparing the root canal in the tooth to be treated,
b) providing a particulate material comprising:
(i) about 20 to about 80 wt. % tricalcium silicate;
about 20 to about 50 wt. % dicalcium silicate;
about 1 to about 20 wt. % tricalcium aluminate,
about 1 to about 20 wt. % tetracalcium aluminoferrite;
about 1 to about 15 wt. % of at least one of the following selected from the group consisting of calcium phosphate, calcium sulfate, silica, alumina, calcium oxide, calcium hydroxide, and mixtures thereof; and
about 1 to about 50 wt. % radiopaque component;
wherein the particulate material has an average particle size in the range of about 1 μm to about 40 μm and has a surface area in the range of 0.5 to 3.0 m 2 /g;

c) providing about 1% to about 80% by weight of a liquid carrier including:
(i) about 5 to about 40 wt. % water-soluble polymer; and
(ii) water; and

d) mixing the particulate material with the liquid carrier to form a dental composition; and
e) introducing the composition into the tooth from coronal or apical openings.

9. The method of claim 8 , wherein the water-soluble polymer is selected from the group consisting of polyvinyl alcohols, polyvinyl-pyrrolidone (PVP), partially hydrolyzed polyvinyl acetates, (PVAc), polyacrylic acid (PAA), and polymethacrylic acid (PMA), hyaluronic acid, water-soluble poly-saccharides, poly amino-acids, and mixtures thereof.

10. The method of claim 8 , wherein the composition further comprises a humectant.

11. The method of claim 8 , wherein the composition further comprises about 1 to about 30% by weight of hydroxyapatite.

12. The method of claim 8 , wherein the composition comprises about 1 to about 40% by weight of the radiopaque component.

13. The method of claim 12 , wherein the radiopaque component is selected from the group consisting of bismuth oxide, barium sulfate, tantalum oxide, cerium oxide, tin oxide, zirconium oxide compounds and radiopaque glasses containing tantalum, barium and strontium, and mixtures thereof.

14. The method of claim 8 , wherein the method comprises using the composition to seal at least a portion of the tooth.

15. The method of claim 8 , wherein the method comprises using the composition to repair root perforations.

16. The method of claim 8 , wherein the method comprises using the composition to repair root resorption.

17. The method of claim 8 , wherein the method comprises using the composition to fill root ends.

18. The method of claim 8 , wherein the method comprises using the composition to cap at least a portion of the pulp that has been exposed.

19. The method of claim 8 , wherein the method comprises using the composition to line a cavity preparation where a pulp-exposure is possible.

20. The method of claim 8 , wherein the method comprises using the composition to obturate root canals.

21. The method of claim 8 , wherein the method comprises using the composition to cover a root access opening in a root after a pulpotomy has been performed.

22. The method of claim 8 , wherein the method comprises using the composition to seal a root canal after gutta-percha has been introduced into the canal.

23. The method of claim 8 , wherein the composition further comprises anti-bacterial and/or anti-microbial agents.

24. The method of claim 23 , wherein the anti-microbial agent includes chlorhexidine gluconate.

25. A dental composition comprising:
a) about 1 to about 80% by weight of particulate material including:
(i) about 20 to about 50 wt. % dicalcium silicate;
(ii) about 1 to about 20 wt. % tricalcium aluminate,
(iii) about 1 to about 20 wt. % tetracalcium aluminoferrite;
(iv) about 1 to about 15 wt. % calcium sulfate; and
(v) about 1 to about 50 wt. % radiopaque component; and
wherein the particulate material has an average particle size in the range of about 1 μm to about 40 μm and has a surface area in the range of 0.5 to 3.0 m 2 /q;

b) about 1% to about 80% by weight of a liquid carrier including:
(i) about 5% to about 40% a water-soluble polymer by weight based on weight of the composition and
(ii) water; and

wherein a ratio of the particulate material to the liquid carrier ranges from 3:1 to 5:1; and
wherein the composition has a compressive strength of greater than 30 MPa.

26. The dental composition of claim 25 , wherein the particulate material has an average particle size in the range of about 1 μm to about 15 μm.

27. The dental composition of claim 25 , wherein the radiopacifier is bismuth oxide.

28. The dental composition of claim 25 , wherein the water-soluble polymer is selected from the group consisting of polyvinyl alcohols, polyvinyl-pyrrolidone (PVP), partially hydrolyzed polyvinyl acetates, (PVAc), polyacrylic acid (PAA), and polymethacrylic acid (PMA), hyaluronic acid, water-soluble poly-saccharides, poly amino-acids, and mixtures thereof.

29. The dental composition of claim 1 , wherein:
(i) the water-soluble polymer is present in an amount of about 5% to about 40% by weight of the dental composition, and
(ii) the water is present in an amount of about 15% to about 30% by weight of the dental composition.

30. The method of claim 8 , wherein a ratio of the particulate material to t

Assignees

• Dentsply Int Inc
• Dentsply Sirona Inc

Inventors

• Primus Carolyn M
• Gutmann James L
• Breuer Miklos M
• Jefferies Steven R

Classifications

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61K6/54 Primary

  Filling; Sealing · CPC title

• A61K6/70

  comprising inorganic additives · CPC title