Method for treating nociceptive pain and burns with brazilian green propolis alcohol extract

Patent metadata

Field	Value
Publication number	US-2022409673-A1
Application number	US-202117362083-A
Country	US
Kind code	A1
Filing date	Jun 29, 2021
Priority date	Jun 29, 2021
Publication date	Dec 29, 2022
Grant date	—

Abstract

A method for treating or preventing nociceptive pain by administering an ethanol extract of Brazilian green propolis and compositions comprising this extract.

First claim

1 . A method for treating nociceptive pain from a burn comprising:
administering to a subject in need of treatment for nociceptive pain from a bum afferently transmitted via non-myelinated C fibers a composition comprising an ethanol extract of Brazilian green propolis (“BGP”).

2 . The method of claim 1 , wherein the pain from the burn is non-inflammatory pain.

3 . The method of claim 1 , wherein the nociceptive pain is an early phase response mediated by myelinated A-sigma, A-beta, or A-alpha fibers.

4 . The method of claim 1 , wherein the nociceptive pain further comprises late phase response resulting from an inflammatory response in combination with activation of N-methyl-d-aspartate (NMDA) and non-NMDA receptors and NO cascade).

5 . The method of claim 1 , wherein the ethanol extract of BGP is produced by extracting BGP with an aqueous solution of at least 70% ethanol.

6 . The method of claim 1 , wherein the composition further comprises an oil extract of BGP.

7 . The method of claim 1 , wherein the composition further comprises a vegetable oil extract of BGP.

8 . The method of claim 1 , wherein the composition further comprises a vegetable oil extract of BGP that has been emulsified with the ethanol extract of BGP.

9 . The method of claim 1 , where the composition further comprises a NSAID or an opioid.

10 . The method of claim 1 , wherein the composition further comprises a sunblock or sunscreen and is topically administered to the subject.

11 . The method of claim 1 , wherein the composition is topically administered to the subject.

12 . The method of claim 1 , wherein the composition is administered to the subject prior to a burn.

13 . The method of claim 1 , further comprising
exposing at least a portion of the burn of the subject in need of treatment to UV light at an intensity of 5-50 mW/cm 2 for up to ½ hour ½ hour or less prior to administering the composition comprising the BGP ethanol extract to the burn wherein the UV light is in a wavelength range of 280-400 nm.

14 . A gel or spray comprising an ethanol extract of BGP and an excipient suitable for application to a burn.

15 . The gel or spray of claim 14 , further comprising an oil extract of BGP.

16 . The gel or spray of claim 14 , further comprising an NSAID or opioid.

17 . The gel or spray of claim 14 that comprises a hydrogel.

18 . The gel or spray of claim 14 that comprises a sunscreen or sunblock.

19 . A burn dressing comprising an ethanol extract of BGP.

20 . The burn dressing of claim 19 , further comprising an oil extract of BGP.

Assignees

• Univ Imam Abdulrahman Bin Faisal

Inventors

• Al-Hariri Mohammed Taha Ali
• Abualait Turki Saeed Mohammed

Classifications

• A61K2236/333

  using mixed solvents, e.g. 70% EtOH · CPC title

• A61K2236/35

  Extraction with lipophilic solvents, e.g. Hexane or petrol ether · CPC title

• A61K35/644 Primary

  Beeswax; Propolis; Royal jelly; Honey · CPC title

• A61K9/7007

  Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence) · CPC title

• A61N5/0616

  Skin treatment other than tanning · CPC title