Coated solid dosage forms

Patent metadata

Field	Value
Publication number	US-9827203-B2
Application number	US-201615218099-A
Country	US
Kind code	B2
Filing date	Jul 25, 2016
Priority date	Feb 14, 2011
Publication date	Nov 28, 2017
Grant date	Nov 28, 2017

Abstract

The invention is associated with ingestible film coated solid dosage forms comprising natural honey in the coating applied to such forms. The natural honey of the film coated solid dosage form is of sufficient level to be perceived by the user while avoiding sticking to each other or the packaging with which they are in contact and, or storage.

First claim

What is claimed is:

1. A tablet comprising:
a film coating wherein the film coating comprises from about 10% to about 25% sticky natural honey; and
an inner core comprising an active selected from the group consisting of decongestants, pain relievers, antitussives, antihistamines, anesthetics, expectorants and combinations thereof;
wherein the tablet has a static coefficient of friction value from about 0.15 to about 0.40.

2. The tablet of claim 1 wherein the film coating comprises from about 13% to about 18% sticky natural honey.

3. The tablet of claim 1 wherein the film coating further comprises from about 0.05% to about 5% sweetener, by weight of the film coating.

4. The tablet of claim 1 wherein the anesthetic is selected from the group consisting of phenol, menthol, dyclonine HCl, benzocaine, lidocaine, hexylresorcinol, and combinations thereof.

5. The tablet of claim 1 wherein the active comprises a decongestant, a pain reliever, and an antitussive.

6. The tablet of claim 5 wherein the decongestant is phenylephrine HCl, the pain reliever is acetaminophen, and the antitussive is dextromethorphan HBr.

7. The tablet of claim 1 wherein the inner core further comprises a vitamin.

8. The tablet of claim 1 further comprising a mineral, metal, or element selected from the group consisting of zinc, iron, calcium, iodine, copper, selenium and combinations thereof.

9. The tablet of claim 1 further comprising a sensory agent selected from the group consisting of coolants, salivating agents, warming agents and combinations thereof.

10. The tablet of claim 1 wherein the inner core further comprises an excipient selected from the group consisting of microcrystalline cellulose, dicalcium phosphate, stearic acid, magnesium stearate, corn starch, lactose, sodium crosscarmellose, sodium starch glycolate, polyvinylpyrollidone, gelatin, and combinations thereof.

11. A tablet comprising:
a film coating wherein the film coating comprises from about 10% to about 25% sticky natural honey; and
an inner core comprising dextromethorphan HBr;
wherein the tablet has a static coefficient of friction value from about 0.15 to about 0.40.

12. The tablet of claim 11 wherein the inner core further comprises guaifenesin.

13. The tablet of claim 11 wherein the film coating further comprises from about 0.5% to about 3.0% of a colorant, by weight of the film coating.

14. The solid dosage form of claim 11 wherein the film coating further comprises propylene glycol.

15. A tablet comprising:
a film coating wherein the film coating comprises from about 10% to about 25% sticky natural honey; and
an inner core comprising diphenhydramine; wherein the tablet has a static coefficient of friction value from about 0.15 to about 0.40.

16. The tablet of claim 15 wherein the inner core further comprises 5 mg phenylephrine HCl.

17. The tablet of claim 15 wherein the inner core further comprises from about 200 mg to about 350 mg acetaminophen.

18. The tablet of claim 15 wherein the film coating further comprises from about 0.05% to about 5% sweetener, by weight of the film coating.

19. The tablet of claim 15 wherein the inner core further comprises an excipient selected from the group consisting of microcrystalline cellulose, dicalcium phosphate, stearic acid, magnesium stearate, corn starch, lactose, sodium crosscarmellose, sodium starch glycolate, polyvinylpyrollidone, gelatin, and combinations thereof.

Assignees

• Procter & Gamble

Inventors

• Stella Mark Edward
• Knights Elissa Nicole

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61K9/2068

  Compounds of unknown constitution, e.g. material from plants or animals (oils, fats, waxes, shellac A61K9/2013) · CPC title

• A61K31/135

  having aromatic rings {, e.g. ketamine, nortriptyline (methadone A61K31/137)} · CPC title

• A61K31/137

  Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone} · CPC title

• A61K9/2893

  Tablet coating processes (mechanical aspects A61J3/06) · CPC title