Tiny nanoparticles for magnetic resonance imaging applications

Patent metadata

Field	Value
Publication number	US-2020023084-A1
Application number	US-201816184379-A
Country	US
Kind code	A1
Filing date	Nov 8, 2018
Priority date	Nov 8, 2017
Publication date	Jan 23, 2020
Grant date	—

Abstract

A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging.

First claim

What is claimed is:

1 . A method of T 1 -weighted magnetic resonance imaging comprising:
administering a zwitterionic iron oxide nanoparticle having a saturation magnetization of less than 30 emu/g [Fe] to a subject; creating an image by processing T 1 data of the zwitterionic iron oxide nanoparticle.

2 . The method of claim 1 , wherein a hydrodynamic diameter of the zwitterionic iron oxide nanoparticle is less than 4 nm.

3 . The method of claim 1 , wherein the hydrodynamic diameter of the zwitterionic iron oxide nanoparticle is 3.1 nm or less.

4 . The method of claim 1 , wherein an inorganic core of the zwitterionic iron oxide nanoparticle has a size of less than 2.5 nm.

5 . The method of claim 1 , wherein an inorganic core of the zwitterionic iron oxide nanoparticle has a size of less than 2 nm.

6 . The method of claim 1 , wherein an inorganic core of the zwitterionic iron oxide nanoparticle has a size that cannot be measured by transmission electron microscopy.

7 . The method of claim 1 , wherein the zwitterionic iron oxide nanoparticle has r 1 and r 2 relaxivity measurements with a r 2 /r 1 ratio of less than 2.0 at 1.5 Tesla.

8 . The method of claim 1 , wherein the zwitterionic iron oxide nanoparticle has r 1 and r 2 relaxivity measurements with a r 2 /r 1 ratio of about 1.1 at 1.5 Tesla.

9 . A T 1 contrast agent for magnetic resonance imaging or magnetic resonance angiography comprising a zwitterionic iron oxide nanoparticle having a saturation magnetization of less than 30 emu/g [Fe].

10 . The T 1 contrast agent of claim 9 , wherein a hydrodynamic diameter of the zwitterionic iron oxide nanoparticle is less than 4 nm.

11 . The T 1 contrast agent of claim 9 , wherein a hydrodynamic diameter of the zwitterionic iron oxide nanoparticle is 3.1 nm or less.

12 . The T 1 contrast agent of claim 9 , wherein an inorganic core of the zwitterionic iron oxide nanoparticle has a size of less than 2.5 nm.

13 . The T 1 contrast agent of claim 9 , wherein an inorganic core of the zwitterionic iron oxide nanoparticle has a size of less than 2 nm.

14 . The T 1 contrast agent of claim 9 , wherein an inorganic core of the zwitterionic iron oxide nanoparticle has a size that cannot be measured by transmission electron microscopy.

15 . The T 1 contrast agent of claim 9 , wherein the zwitterionic iron oxide nanoparticle has r 1 and r 2 relaxivity measurements with a r 2 /r 1 ratio of less than 2.0 at 1.5 Tesla.

16 . The T 1 contrast agent of claim 9 , wherein the zwitterionic iron oxide nanoparticle has r 1 and r 2 relaxivity measurements with a r 2 /r 1 ratio of about 1.1 at 1.5 Tesla.

17 . A nanoparticle composition comprising a plurality of zwitterionic iron oxide nanoparticle having a saturation magnetization of less than 30 emu/g [Fe].

18 . The nanoparticle composition of claim 17 , wherein a hydrodynamic diameter of the zwitterionic iron oxide nanoparticle is less than 4 nm.

19 . The nanoparticle composition of claim 17 , wherein a hydrodynamic diameter of the zwitterionic iron oxide nanoparticle is 3.1 nm or less.

20 . The nanoparticle composition of claim 17 , wherein an inorganic core of the zwitterionic iron oxide nanoparticle has a size of less than 2.5 nm.

21 . The nanoparticle composition of claim 17 , wherein an inorganic core of the zwitterionic iron oxide nanoparticle has a size of less than 2 nm.

Assignees

• Massachusetts Inst Technology

Inventors

• Bawendi Moungi G
• Wei He
• Bruns Oliver T
• Hansen Eric C

Classifications

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• A61K49/1833 Primary

  having a (super)(para)magnetic core coated or functionalised with a small organic molecule (oligomeric, polymeric, dendrimeric A61K49/1851) · CPC title

• A61K49/1839 Primary

  the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid · CPC title