New ketogenic diet and its use in treating the critically ill

Patent metadata

Field	Value
Publication number	US-2016175378-A1
Application number	US-201615056473-A
Country	US
Kind code	A1
Filing date	Feb 29, 2016
Priority date	Sep 4, 2013
Publication date	Jun 23, 2016
Grant date	—

Abstract

The present invention provides a novel diet for the critically ill, a ketogenic diet. Many of the problems found in the critically ill, such as hyperglycemia, excessive inflammatory response, and fluid retention, can be traced to the normal high carbohydrate diet used in hospital treatment. By replacing the high carbohydrate diet with a diet low in carbohydrates and higher in the proper fats, many of these problems are ameliorated. The preferred fats have high omega-3 content or are MCT's.

First claim

What is claimed is:

1 . A ketogenic diet for treating critically ill patients having at least a fat portion and a protein portion, the diet comprising:
a fat portion that supplies 50-95% of the calories; and a protein portion that supplies 5-35% of the calories; and, wherein any carbohydrate in the diet is limited to 0-10% of the calories.

2 . The ketogenic diet of claim 1 wherein:
at least the majority of said fat calories are supplied by an oil rich in DHA and EPA.

3 . The ketogenic diet of claim 1 wherein:
the fat portion comprises linoleic acid, wherein the linoleic acid content of the fat portion is limited to less than 3% of said fat calories.

4 . The ketogenic diet of claim 3 wherein said diet contains less than 1%, by calorie, linoleic acid.

5 . The ketogenic diet of claim 1 wherein said ketogenic diet provides 50-90% of the caloric needs of the critically ill patient.

6 . The ketogenic diet of claim 1 wherein the majority of said fat calories are supplied by fats selected from the group consisting of medium chain triglycerides, high oleic acid containing oils and saturated fats.

7 . The ketogenic diet of claim 6 wherein said diet contains at least 0.5% by calorie arachidonic acid.

8 . The ketogenic diet of claims 7 wherein said diet contains less than 1%, by calorie linoleic acid.

9 . The ketogenic diet of claims 1 further comprising all essential micronutrients.

10 . The ketogenic diet of claim 1 wherein said diet is in the form of enteral nutrition.

11 . The ketogenic diet of claim 1 wherein said diet is in the form of parenteral nutrition.

12 . The ketogenic diet of claim 1 wherein said diet comprises 50-80% of the calories in the form of fat, 10-35% of the calories in the form of protein, and 0-10% of the calories of the form of carbohydrate.

13 . A method of providing nutritional support to a critically ill patient comprising:
administering a ketogenic diet to said patient and limiting the carbohydrate to less than 10% of the total calories given to said patient.

14 . The method of claim 13 wherein said ketogenic diet comprises 50-95% of the calories in the form of fat, 5-40% of the calories in the form of protein, and 0-10% of the calories of the form of carbohydrate.

15 . The method of claim 14 wherein said ketogenic diet comprises 50-80% of the calories in the form of fat, 10-35% of the calories in the form of protein, and 0-10% of the calories in the form of carbohydrate.

16 . The method of claim 14 wherein the majority of the fat in the diet is a fat is selected from the group consisting of oils rich in DHA and EPA, concentrated omega-3 rich oils, MCT's and high oleic acid containing oils.

17 . The method of claim 14 wherein the linoleic acid content of the diet is less than 3% of the total caloric intake.

18 . The method of claim 17 wherein the linoleic acid content of the diet is less than 1% of the total caloric intake.

19 . The method of claim 13 wherein the ketogenic diet provides 50-90% of the energy expenditure of the patient.

20 . The method of claim 13 wherein said ketogenic diet is in the form of enteral nutrition.

21 . The method of claim 13 wherein said ketogenic diet is in the form of parenteral nutrition.

22 . The method of claim 13 wherein the carbohydrate in the diet is less than 100 g/24 hours.

23 . The method of claim 22 wherein the carbohydrate in the diet is less than 85 g/24 hours.

Assignees

• Beth Israel Hospital
• Childrens Medical Center

Inventors

• Bistrain Bruce R
• Puder Mark

Classifications

• A23L1/293

  Human Necessities · mapped topic

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61K38/011 Primary

  from plants · CPC title

• A23L1/3006

  Human Necessities · mapped topic

• A61K31/202

  having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) · CPC title