Nutritional compositions including calcium beta-hydroxy-beta-methylbutyrate, protein and low levels of electrolytes

Patent metadata

Field	Value
Publication number	US-9757345-B2
Application number	US-201314430046-A
Country	US
Kind code	B2
Filing date	Sep 20, 2013
Priority date	Sep 21, 2012
Publication date	Sep 12, 2017
Grant date	Sep 12, 2017

Abstract

Disclosed are nutritional compositions, and methods of using and making the nutritional compositions, that include calcium beta-hydroxy-beta-methylbutyrate and protein. The calcium beta-hydroxy-beta-methylbutyrate is in sequestered or ion-exchanged form to reduce the interaction of the calcium with the protein in the nutritional composition and improve the overall stability of the nutritional composition.

First claim

What is claimed is:

1. A liquid nutritional composition comprising sequestered calcium beta-hydroxy-beta-methylbutyrate, protein, potassium, sodium and phosphorus, wherein the potassium concentration is less than 800 ppm, the sodium concentration is less than 400 ppm, and the phosphorus concentration is less than 500 ppm.

2. The liquid nutritional composition of claim 1 , wherein the potassium is in a concentration of less than 500 ppm, the sodium is in a concentration of less than 350 ppm, and the phosphorus is in a concentration of less than 400 ppm.

3. The liquid nutritional composition of claim 1 further comprising fat and carbohydrate.

4. The liquid nutritional composition of claim 3 , wherein the fat is selected from the group consisting of high oleic safflower oil, high oleic sunflower oil, canola oil, soy oil, corn oil, and combinations thereof.

5. The liquid nutritional composition of claim 3 , wherein the fat includes at least one polyunsaturated fatty acid.

6. The liquid nutritional composition of claim 5 , wherein the at least one polyunsaturated fatty acid is selected from the group consisting of docosahexaenoic acid, arachidonic acid, eicosapentaenoic acid, and combinations thereof.

7. The liquid nutritional composition of claim 3 , wherein the protein is selected from the group consisting of milk protein concentrate, milk protein isolate, soy protein concentrate, soy protein isolate, intact pea protein concentrate, intact pea protein isolate, sodium caseinate, calcium caseinate, whey protein concentrate, whey protein isolate, and combinations thereof.

8. The liquid nutritional composition of claim 3 , wherein the carbohydrate is selected from the group consisting of maltodextrin, corn syrup solids, corn syrup, tapioca dextrin, isomaltulose, digestion resistant maltodextrin, sucromalt, maltitol powder, fructose, glycerin, fructooligosaccharide, soy fiber, corn fiber, guar gum, konjac flour, polydextrose, and combinations thereof.

9. The liquid nutritional composition of claim 3 , further comprising a soy fiber.

10. The liquid nutritional composition of claim 3 , further comprising a prebiotic.

11. The liquid nutritional composition of claim 10 , wherein the prebiotic is selected from the group consisting of oligofructose, fructooligosaccharide, galactooligosaccharide, inulin, and combinations thereof.

12. The liquid nutritional composition of claim 3 , comprising protein in an amount of from about 1% to about 30% by weight, carbohydrate in an amount of from about 3% to about 65% by weight, and fat in an amount of from about 1% to about 20% by weight, wherein the protein comprises from about 1% to about 20% by weight intact pea protein.

13. The liquid nutritional composition of claim 12 , wherein the protein comprises intact pea protein concentrate, milk protein concentrate, and soy protein isolate.

14. A method of reducing muscle loss in an individual with a metabolic disorder, diabetes, or chronic kidney dysfunction, the method comprising administering a liquid nutritional composition comprising sequestered calcium beta-hydroxy-beta-methylbutyrate, protein, potassium, sodium and phosphorus, wherein the potassium concentration is less than 800 ppm, the sodium concentration is less than 400 ppm, and the phosphorus concentration is less than 500 ppm to the individual with the metabolic disorder, diabetes, or chronic kidney dysfunction.

15. A liquid nutritional composition comprising sequestered calcium beta-hydroxy-beta-methylbutyrate, protein, and potassium, wherein the potassium concentration is less than 800 ppm.

16. The liquid nutritional composition of claim 15 , wherein the potassium is in a concentration of from about 300 ppm to about 500 ppm.

17. The liquid nutritional composition of claim 15 further comprising fat and carbohydrate.

18. The liquid nutritional composition of claim 17 comprising protein in an amount of from about 1% to about 30% by weight, carbohydrate in an amount of from about 3% to about 65% by weight, and fat in an amount of from about 1% to about 20% by weight, wherein the protein comprises from about 1% to about 20% by weight intact pea protein.

19. The liquid nutritional composition of claim 1 , wherein the sequestered calcium beta-hydroxy-beta-methylbutyrate is at least one of a glycine sequestrate, a gluconic acid sequestrate, an alginate sequestrate, or a phytate sequestrate.

20. The liquid nutritional composition of claim 15 , wherein the sequestered calcium beta-hydroxy-beta-methylbutyrate is at least one of a glycine sequestrate, a gluconic acid sequestrate, an alginate sequestrate, or a phytate sequestrate.

21. The liquid nutritional composition of claim 1 , wherein the composition has a pH of 5.5 to 7.3.

Assignees

• Abbott Lab

Inventors

• Walton Joseph
• Stepp Emily
• Devitt-Maicher Amy
• Wolf David
• Mustad Vikkie
• Baxter Jeffrey
• Mazer Terrence
• Marchio Amy

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61K33/42

  Phosphorus; Compounds thereof · CPC title

• A23L33/12

  Fatty acids or derivatives thereof · CPC title

• A61K31/202

  having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) · CPC title