Uric acid-lowering agent

Patent metadata

Field	Value
Publication number	US-9650415-B2
Application number	US-201414787677-A
Country	US
Kind code	B2
Filing date	Jun 20, 2014
Priority date	Jun 20, 2014
Publication date	May 16, 2017
Grant date	May 16, 2017

Abstract

A uric acid-lowering agent containing, as an active ingredient, a tyrosine-containing cyclic dipeptide selected from the group consisting of cyclotryptophanyltyrosine, cycloseryltyrosine, cycloprolyltyrosine, cyclotyrosylglycine, cyclotyrosyltyrosine, cyclophenylalanyltyrosine, cycloleucyltyrosine, cyclolysyltyrosine, cyclohistidyltyrosine, cycloalanyltyrosine, cycloglutamyltyrosine, cyclovalyltyrosine, cycloisoleucyltyrosine, cyclothreonyltyrosine, cycloaspartyltyrosine, cycloasparaginyltyrosine, cycloglutaminyltyrosine, cycloarginyltyrosine, cyclomethionyltyrosine, and cyclotyrosylcysteine, or a salt thereof. The uric acid-lowering agent of the present invention has an excellent action of lowering a uric acid level, and the uric acid-lowering agent is useful in, for example, prevention or treatment of hyperuricemia, gout or the like.

First claim

The invention claimed is:

1. A composition for lowering a uric acid level, comprising a uric acid-lowering agent, wherein the uric acid-lowering agent comprises one or more tyrosine-comprising cyclic dipeptides selected from a first group consisting of cyclotyrosyltyrosine, cyclophenylalanyltyrosine and cycloleucyltyrosine, or salts thereof, and one or more tyrosine-comprising cyclic dipeptides selected from a second group consisting of cyclotryptophanyltyrosine, cycloseryltyrosine, cycloprolyltyrosine, cyclotyrosylglycine, cyclolysyltyrosine, cyclohistidyltyrosine, cycloalanyltyrosine, cycloglutamyltyrosine, cyclovalyltyrosine, cycloisoleucyltyrosine, cyclothreonyltyrosine, cycloaspartyltyrosine, cycloasparaginyltyrosine, cycloglutaminyltyrosine, cycloarginyltyrosine, cyclomethionyltyrosine, and cyclotyrosylcysteine, or salts thereof, and
wherein a total amount of the tyrosine-comprising cyclic dipeptides from the first group in the uric acid-lowering agent is from 5% by weight to 90% by weight relative to a total amount of the uric acid-lowering agent, so that the tyrosine-comprising cyclic dipeptides from the first group are present in an effective amount for lowering the uric acid level,
wherein the one or more tyrosine-comprising cyclic dipeptides from the first group comprises cyclophenylalanyltyrosine, and the one or more tyrosine-comprising cyclic dipeptides from the second group comprises cyclotyrosylglycine, and
wherein a ratio of cyclophenylalanyltyrosine to cyclotyrosylglycine is from 90/10 to 30/70.

2. The composition for lowering a uric acid level according to claim 1 , wherein the composition is a treated product obtained by heat-treating a solution comprising a soybean peptide.

3. A composition for inhibiting a xanthine oxidase comprising a xanthine oxidase inhibitor, wherein the xanthine oxidase inhibitor comprises one or more tyrosine-comprising cyclic dipeptides selected from a first group consisting of cyclotyrosyltyrosine, cyclophenylalanyltyrosine, and cycloleucyltyrosine, or salts thereof, and one or more tyrosine-comprising cyclic dipeptides selected from a second group consisting of cyclotryptophanyltyrosine, cycloseryltyrosine, cycloprolyltyrosine, cyclotyrosylglycine, cyclolysyltyrosine, cyclohi stidyltyrosine, cycloalanyltyrosine, cycloglutamyltyrosine, cyclovalyltyrosine, cycloi soleucyltyrosine, cyclothreonyltyrosine, cycloaspartyltyrosine, cycloasparaginyltyrosine, cycloglutaminyltyrosine, cycloarginyltyrosine, cyclomethionyltyrosine, and cyclotyrosylcysteine, or salts thereof, and
wherein a total amount of the tyrosine-comprising cyclic dipeptides from the first group in the xanthine oxidase inhibitor is from 5% by weight to 90% by weight relative to a total amount of the xanthine oxidase inhibitor, so that the tyrosine-comprising cyclic dipeptides from the first group are present in an effective amount for inhibiting the xanthine oxidase,
wherein the one or more tyrosine-comprising cyclic dipeptides from the first group comprises cyclophenylalanyltyrosine, and the one or more tyrosine-comprising cyclic dipeptides from the second group comprises cyclotyrosylglycine, and
wherein a ratio of cyclophenylalanyltyrosine to cyclotyrosylglycine is from 90/10 to 30/70.

4. The composition for inhibiting a xanthine oxidase according to claim 3 , wherein the composition is a treated product obtained by heat-treating a solution comprising a soybean peptide.

5. A method for lowering a uric acid level, comprising the step of administering an effective amount of a composition comprising a uric acid-lowering agent to an individual in need of lowering the uric acid level,
wherein the uric acid-lowering agent comprises one or more tyrosine-comprising cyclic dipeptides selected from a first group consisting of cyclotyrosyltyrosine, cyclophenylalanyltyrosine and cycloleucyltyrosine, or salts thereof, and one or more tyrosine-comprising cyclic dipeptides selected from a second group consisting of cyclotryptophanyltyrosine, cycloseryltyrosine, cycloprolyltyrosine, cyclotyrosylglycine, cyclolysyltyrosine, cyclohistidyltyrosine, cycloalanyltyrosine, cycloglutamyltyrosine, cyclovalyltyrosine, cycloisoleucyltyrosine, cyclothreonyltyrosine, cycloaspartyltyrosine, cycloasparaginyltyrosine, cycloglutaminyltyrosine, cycloarginyltyrosine, cyclomethionyltyrosine, and cyclotyrosylcysteine, or salts thereof.

6. The composition for lowering a uric acid level according to claim 1 , wherein the one or more tyrosine-comprising cyclic dipeptides from the first group further comprises cyclotyrosyltyrosine, and wherein a ratio of cyclophenylalanyltyrosine to cyclotyrosyltyrosine in the uric acid-lowering agent is from 95/5 to 35/65.

7. The composition for lowering a uric acid level according to claim 1 , wherein the total amount of the tyrosine-comprising cyclic dipeptides from the first group in the uric acid-lowering agent is at least 10% by weight relative to the total amount of the uric acid-lowering agent.

8. The composition for lowering a uric acid level according to claim 1 , wherein the total amount of the tyrosine-comprising cyclic dipeptides from the first group in the uric acid-lowering agent is at most 60% by weight relative to the total amount of the uric acid-lowering agent.

9. The composition for inhibiting a xanthine oxidase according to claim 3 , wherein the one or more tyrosine-comprising cyclic dipeptides from the first group further comprises cyclotyrosyltyrosine, and wherein a ratio of cyclophenylalanyltyrosine to cyclotyrosyltyrosine in the xanthine oxidase inhibitor is from 95/5 to 35/65.

10. The composition for inhibiting a xanthine oxidase according to claim 3 , wherein the total amount of the tyrosine-comprising cyclic dipeptides from the first group in the xanthine oxidase inhibitor is at least 10% by weight relative to the total amount of the xanthine oxidase inhibitor.

11. The composition for inhibiting a xanthine oxidase according to claim 3 , wherein the total amount of the tyrosine-comprising cyclic dipeptides from the first group in the xanthine oxidase inhibitor is at most 60% by weight relative to the total amount of the xanthine oxidase inhibitor.

12. The method for lowering a uric acid level according to claim 5 , wherein the composition is a treated product obtained by heat-treating a solution comprising a soybean peptide.

13. The method for lowering a uric acid level according to claim 5 , wherein the one or more tyrosine-comprising cyclic dipeptides from the first group comprises cyclophenylalanyltyrosine and cyclotyrosyltyrosine, and wherein a ratio of cyclophenylalanyltyrosine to cyclotyrosyltyrosine in the uric acid-lowering agent is from 95/5 to 35/65.

14. The method for lowering a uric acid level according to claim 5 , wherein the one or more tyrosine-comprising cyclic dipeptides from the first group comprises cyclophenylalanyltyrosine, and the one or more tyrosine-comprising cyclic dipeptides from the second group comprises cyclotyrosylglycine, and wherein a ratio of cyclophenylalanyltyrosine to cyclotyrosylglycine is from 90/10 to 30/70.

15. The method for lowering a uric acid level according to claim 5 , wherein the total amount of the tyrosine-comprising cyclic dipeptides from the first group in the uric acid-lowering agent is at least 10% by weight relative to the total amount of the uric acid-lowering agent.

16. The method for lowering a uric acid level according to claim 5 , wherein the total amount of the tyrosine-comprising cyclic dipeptides from the first group in the uric acid-lowering agent is at most 60% by weight relative to the total amount of the uric acid-lowe

Assignees

• Suntory Holdings Ltd

Inventors

• Suzuki Toshihide
• Fukizawa Shinya
• Beppu Yoshinori
• Watanabe Hiroshi

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• C07K5/12

  Cyclic peptides {with only normal peptide bonds in the ring} · CPC title

• A61K38/005

  Enzyme inhibitors (protease inhibitors A61K38/55) · CPC title

• A61K38/05

  Dipeptides · CPC title

• A61K38/011

  from plants · CPC title