Technologies for acoustoelectronic nanotweezing

Patent metadata

Field	Value
Publication number	US-12564865-B2
Application number	US-202217883883-A
Country	US
Kind code	B2
Filing date	Aug 9, 2022
Priority date	Aug 10, 2021
Publication date	Mar 3, 2026
Grant date	Mar 3, 2026

Abstract

Technologies for acoustoelectronic manipulation of micro/nano particles include a system having a piezoelectric substrate coupled to one or more acoustic transducers and a fluid layer positioned above the substrate. Micro/nano particles are introduced to the fluid, which can be in the form of a droplet or in a confined channel, and a signal is applied to the acoustic transducer. One or more parameters of the signal are varied after introducing the micro/nano particles into the fluid. The parameters may include amplitude, frequency, or phase of the signal. The system may include one or more acoustic transducers. Multiple signals may be applied to the acoustic transducers. Wave superposition of acoustic waves in the substrate manipulates micro/nano particles in the fluid. The nanoparticles may include carbon nanotubes, nanowires, nanofibers, graphene flakes, quantum dots, SERS probes, exosomes, vesicles, DNA, RNA, antibodies, antigens, macromolecules, or proteins.

First claim

The invention claimed is:

1 . A method for acoustoelectronic manipulation of nanoparticles, the method comprising:
introducing nanoparticles into a fluid layer positioned over a first surface of a piezoelectric substrate; applying a first signal to a first acoustic transducer set, wherein the first acoustic transducer set is coupled to the first surface of the piezoelectric substrate and spaced apart from the fluid layer; and varying a parameter of the first signal after introducing the nanoparticles into the fluid layer.

2 . The method of claim 1 , wherein applying the first signal to the first acoustic transducer set comprises creating a standing acoustic wave in the piezoelectric substrate, wherein the standing wave is in-plane relative to the first surface of the piezoelectric substrate.

3 . The method of claim 1 , wherein the first piezoelectric substrate comprises a y-cut, 41 degrees rotated lithium niobate crystal.

4 . The method of claim 3 , wherein the first signal comprises an alternating current signal having a frequency of about 38.44 MHz.

5 . The method of claim 1 , wherein varying the parameter of the first signal comprises varying an amplitude, a frequency, or a phase of the first signal.

6 . The method of claim 1 , further comprising applying a second signal to a second acoustic transducer set, wherein the second acoustic transducer set is coupled to the first surface of the piezoelectric substrate and spaced apart from the fluid layer, and wherein the second acoustic transducer set is oriented orthogonally to the first interdigital transducer set.

7 . The method of claim 6 , wherein the first signal and the second signal have a first frequency.

8 . The method of claim 6 , wherein the first signal has a first frequency and the second signal has a second frequency, wherein the first frequency and the second frequency differ by a small amount.

9 . The method of claim 6 , further comprising varying a second parameter of the second signal after introducing the nanoparticles into the fluid layer.

10 . The method of claim 9 , wherein:
varying the parameter of the first signal comprises varying a first phase of the first signal; and varying the second parameter of the second signal comprises varying a second phase of the second signal, wherein the first signal and the second signal have a first frequency.

11 . The method of claim 9 , wherein:
varying the parameter of the first signal comprises varying a first amplitude of the first signal; and varying the second parameter of the second signal comprises varying a second amplitude of the second signal.

12 . The method of claim 1 , further comprising electrically shielding part of the piezoelectric substrate while applying the signal to the first acoustic transducer set.

13 . The method of claim 1 , wherein the nanoparticles have a size between about 1 nm to 100 nm.

14 . The method of claim 1 , wherein the nanoparticles comprise carbon nanotubes, nanowires, nanofibers, graphene flakes, quantum dots, SERS probes, exosomes, vesicles, DNA, RNA, antibodies, antigens, macromolecules, or proteins.

15 . The method of claim 1 , further comprising transferring the nanoparticles to a macroscopic surface after applying the first signal.

16 . A system for acoustoelectronic manipulation of nanoparticles, the system comprising:
a piezoelectric substrate having a first surface; a first acoustic transducer set coupled to the first surface of the piezoelectric substrate; a fluid layer positioned over the first surface of the piezoelectric substrate, wherein the fluid layer is spaced apart from the acoustic transducer set on the first surface; and a controller configured to (i) apply a first signal to a first acoustic transducer set and (ii) vary a parameter of the first signal after introduction of nanoparticles into the fluid layer.

17 . The system of claim 16 , further comprising:
a second acoustic transducer set coupled to the first surface of the piezoelectric substrate and spaced apart from the fluid layer, wherein the second interdigital transducer set is oriented orthogonally or tilted at a predetermined angle relative to the first interdigital transducer set; wherein the controller is further to apply a second signal to the second acoustic transducer set.

18 . The system of claim 17 , wherein the controller is further to vary a second parameter of the second signal after the introduction of the nanoparticles into the fluid layer.

19 . The system of claim 18 , wherein:
to vary the parameter of the first signal comprises to vary a first phase of the first signal, and to vary the second parameter of the second signal comprises to vary a second phase of the second signal, wherein the first signal and the second signal have a first frequency; or to vary the parameter of the first signal comprises to vary a first amplitude of the first signal, and to vary the second parameter of the second signal comprises to vary a second amplitude of the second signal.

20 . The system of claim 16 , further comprising a confined microchannel positioned over the first surface of the piezoelectric substrate, wherein the fluid layer is positioned in the confined microchannel.

Assignees

• Univ Duke

Inventors

• Zhang Peiran
• Rufo Joseph
• Huang Tony Jun

Classifications

• B01L3/502761

  specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules · CPC title

• H10N30/00

  Piezoelectric or electrostrictive devices (integrated devices or assemblies of multiple devices H10N39/00) · CPC title

• B01L2200/0668

  Trapping microscopic beads · CPC title

• B01L2400/0439

  ultrasonic vibrations, vibrating piezo elements · CPC title

• B01L2400/0436

  acoustic forces, e.g. surface acoustic waves [SAW] · CPC title