Gelation of Highly Entangled Hydrophobic Macromolecular Fluid for Ultra-Strong Underwater In-Situ Fast Adhesion to Artery, Lung, Bone and Skin Tissues
US-2024374785-A1 · Nov 14, 2024 · US
US12564656B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12564656-B2 |
| Application number | US-202318192946-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 30, 2023 |
| Priority date | Mar 30, 2022 |
| Publication date | Mar 3, 2026 |
| Grant date | Mar 3, 2026 |
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Provided are compositions and methods that involve viscoelastic poly(lactide-co-caprolactone) (PLCL) mixtures for use in wound healing. The PLCL mixtures provide an improved anti-fibrotic yet tissue-adhesive polymer sealant. The PLCL mixtures can be applied to a variety of wounds arising from surgical and non-surgical tissue damage.
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What is claimed is: 1 . A composition consisting essentially of a mixture of 40 k and 5 k poly(L-lactide-co-caprolactone) (PLCL), wherein the 40 k and 5 k PLCL are present in a 70:30 mass ratio, respectively, wherein the composition is free of poly(lactic-co-glycolic acid) (PLGA), poly(ethylene glycol) (PEG) and nanoparticles, and when in contact with a tissue wound the composition is optionally a solid adhesive.
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