Systems, methods and devices for aerosol spraying of silicone based topical skin adhesives for sealing wounds

Patent metadata

Field	Value
Publication number	US-11518604-B2
Application number	US-202016885426-A
Country	US
Kind code	B2
Filing date	May 28, 2020
Priority date	May 28, 2020
Publication date	Dec 6, 2022
Grant date	Dec 6, 2022

Abstract

An aerosol spray device includes a container having first and second fluid reservoirs disposed therein that are divided from one another. The first fluid reservoir holds a first mixture including a first aerosol propellant and a first part of a silicone based topical skin adhesive that is dissolved in the first aerosol propellant. The second fluid reservoir holds a second mixture including a second aerosol propellant and a second part of the silicone based topical skin adhesive that is dissolved in the second aerosol propellant. An aerosol spray dispensing system is connected with the container, which is configured to combine the first and second mixtures to form the silicone based topical skin adhesive and dispense the silicone based topical skin adhesive from the container as an aerosol spray.

First claim

What is claimed is:

1. An aerosol spray device comprising:
a container including first and second fluid reservoirs disposed therein that are divided from one another;
said first fluid reservoir holding a first mixture including a first aerosol propellant and a first part of a silicone based topical skin adhesive that is dissolved in said first aerosol propellant;
said second fluid reservoir holding a second mixture including a second aerosol propellant and a second part of said silicone based topical skin adhesive that is dissolved in said second aerosol propellant;
wherein said first part of said silicone based topical skin adhesive comprises a vinyl-terminated polydimethylsiloxane polymer, and wherein said second part of said silicone based topical skin adhesive comprises a vinyl-terminated polydimethylsiloxane polymer;
an aerosol spray dispensing system connected with said container that is configured to combine said first and second mixtures to form said silicone based topical skin adhesive and dispense said silicone based topical skin adhesive from said container as an aerosol spray.

2. The aerosol spray device as claimed in claim 1 ; wherein said first mixture comprises a catalyst adapted to precipitate a chemical reaction between said first and second parts of said silicone based topical skin adhesive.

3. The aerosol spray device as claimed in claim 2 ; wherein said catalyst comprises a platinum tetramethyldivinyl disiloxane diethyl maleate complex having the formula:
Pt[(CH 2 ═CH)(CH 3 ) 2 Si] 2 O·(COCH═CHCO)(C 2 H 5 O) 2 .

4. The aerosol spray device as claimed in claim 1 , further comprising:
said first mixture including first silica particles homogenously dispersed in said first aerosol propellant;
said second mixture including second silica particles homogenously dispersed in said second aerosol propellant.

5. The aerosol spray device as claimed in claim 1 , wherein said second mixture further comprises a chain extender mixed with said second part of said silicone based topical skin adhesive.

6. The aerosol spray device as claimed in claim 5 , wherein said chain extender comprises silicon hydrid (SiH) terminated polydimethylsiloxane.

7. The aerosol spray device as claimed in claim 1 , wherein said first and second aerosol propellants comprise low boiling point hydrocarbon compounds.

8. The aerosol spray device as claimed in claim 7 , wherein said low boiling point hydrocarbon compounds are selected from the group consisting of hexane, pentane, butane, isobutene, propane, fluorinated solvents including 1,1-difluoroethane and Solstice® Performance Fluid, ethers including dimethyl ether and diethyl ethyl, and mixtures thereof.

9. The aerosol spray device as claimed in claim 1 , wherein said aerosol spray dispensing system comprises:
a dispensing nozzle connected with an upper end of said container for dispensing said aerosol spray of said silicone based topical skin adhesive;
a dip tube disposed inside said container having an upper end in fluid communication with said dispensing nozzle, and a lower end having a first opening in fluid communication with said first fluid reservoir and a second opening in fluid communication with said second fluid reservoir;
a fluid control valve located inside said container between said dip tube and said dispensing nozzle;
a static mixer extending between said dip tube and said valve for combining said first and second mixtures together to form said silicone based topical skin adhesive.

10. An aerosol spray device comprising:
a container including first and second fluid reservoirs disposed therein that are isolated from one another;
said first fluid reservoir holding a first mixture including a first aerosol propellant, a first part of a silicone based topical skin adhesive that is dissolved in said first aerosol propellant, and first silica particles homogeneously dispersed in said first aerosol propellant;
said second fluid reservoir holding a second aerosol propellant, a second part of said silicone based topical skin adhesive that is dissolved in said second aerosol propellant, and second silica particles homogeneously dispersed in said second aerosol propellant;
wherein said first silica particles comprise first silica fume particles homogenously dispersed in said first propellant, and wherein said second silica particles comprise second silica fume particles homogenously dispersed in said second propellant;
an aerosol spray dispensing system connected with said container that is configured to combine said first and second mixtures for forming said silicone based topical skin adhesive and dispensing said silicone based topical skin adhesive from said container as an aerosol spray.

11. The aerosol spray device as claimed in claim 10 , wherein said first and second propellants comprise low boiling point hydrocarbon compounds.

12. The aerosol spray device as claimed in claim 11 , wherein said low boiling point hydrocarbon compounds are selected from the group consisting of hexane, pentane, butane, isobutene, propane, fluorinated solvents including 1,1-difluoroethane and Solstice® Performance Fluid, ethers including dimethyl ether and diethyl ethyl, and mixtures thereof.

13. The aerosol spray device as claimed in claim 10 , wherein said first mixture further comprises a catalyst mixed with said first part of said silicone based topical skin adhesive, wherein said catalyst comprises a platinum tetramethyldivinyl disiloxane diethyl maleate complex having the formula:
Pt[(CH 2 ═CH)(CH 3 ) 2 Si] 2 O·(COCH═CHCO)(C 2 H 5 O) 2

14. The aerosol spray device as claimed in claim 10 , wherein each of said first and second parts of said silicone based topical skin adhesive comprises a vinyl-terminated polydimethylsiloxane polymer.

15. The aerosol spray device as claimed in claim 10 , wherein said second mixture further comprises a cross-linker and a chain extender mixed with said second part of said silicone based topical skin adhesive.

16. The aerosol spray device as claimed in claim 15 , wherein said cross-linker comprises polymethyl hydro siloxane and said chain extender comprises SiH terminated polydimethylsiloxane.

17. The aerosol spray device as claimed in claim 10 , wherein said aerosol spray dispensing system comprises:
a dispensing nozzle connected with an upper end of said container;
a dip tube disposed inside said container having an upper end in fluid communication with said dispensing nozzle, and a lower end having a first opening in fluid communication with said first fluid reservoir and a second opening in fluid communication with said second fluid reservoir;
a fluid control valve located inside said container and being located between the upper end of said dip tube and said dispensing nozzle;
a static mixer located between said dip tube and said valve for mixing together the contents of said first mixture of said first fluid reservoir with the contents of said second mixture of said second fluid reservoir.

18. An aerosol spray device comprising:
a container including first and second fluid reservoirs disposed therein that are divided from one another;
said first fluid reservoir containing a first mixture including a first part of a silicone based topical skin adhesive;
said second fluid reservoir containing a second mixture including a second part of said silicone based topical skin adhesive;
an aerosol spray dispensing system connected with said container that is configured to combine said first and second mixtures for forming said silicone based topical skin adhesive and di

Assignees

• Ethicon Inc

Inventors

• Ou Duan Li
• Mordas Carolyn J

Classifications

• A61B17/00491 Primary

  Surgical glue applicators · CPC title

• B65D83/32

  Dip-tubes · CPC title

• A61L24/02

  containing inorganic materials · CPC title

• A61L26/0076

  Sprayable compositions · CPC title

• C08G77/20

  containing silicon bound to unsaturated aliphatic groups · CPC title