Wound dressing containing crosslinked gelatin derivative particles

Patent metadata

Field	Value
Publication number	US-11975113-B2
Application number	US-201816642887-A
Country	US
Kind code	B2
Filing date	Aug 31, 2018
Priority date	Sep 4, 2017
Publication date	May 7, 2024
Grant date	May 7, 2024

Abstract

A wound dressing material includes a particle having a crosslinked gelatin derivative, the gelatin derivative having the structure represented by the following formula (1):

GltnNH—CHR 1 R 2   (1)

wherein “Gltn” represents a gelatin residue, R 1 represents an alkyl group having 1-17 carbon atoms, and R 2 represents a hydrogen atom or an alkyl group having 1-17 carbon atoms, and the particle having a particle size ranging from 1 to 1,000 μm.

First claim

What is claimed is:

1. A wound dressing material comprising a particle comprising a thermally crosslinked gelatin derivative, the gelatin derivative comprising the structure represented by the following formula (1):
GltnNH—CHR 1 R 2   (1)

wherein “Gltn” represents a gelatin residue, R 1 represents an alkyl group having 1-17 carbon atoms, and R 2 represents a hydrogen atom or an alkyl group having 1-17 carbon atoms, and
the particle having a particle size ranging from 1 to 1,000 μm.

2. A method for preparing the wound dressing material according to claim 1 , comprising:
preparing the gelatin derivative comprising the structure represented by the aforesaid formula (1);
spray drying a solution of the gelatin derivative or pulverizing the gelatin derivative in solid state to form particles; and
heat treating the formed particles by heating at a temperature of from 140 to 160° C. for at least 3 hours.

3. The wound dressing material according to claim 1 , wherein the gelatin is an alkali-treated gelatin derived from porcine gelatin or Alaska pollock gelatin.

4. The wound dressing material according to claim 3 , wherein the gelatin derivative has a molar ratio of imino group/amino group ranging from 20/80 to 80/20.

5. A method for preparing the wound dressing material according to claim 3 , comprising:
preparing the gelatin derivative comprising the structure represented by the aforesaid formula (1);
spray drying a solution of the gelatin derivative or pulverizing the gelatin derivative in solid state to form particles; and
heat treating the formed particles by heating at a temperature of from 140 to 160° C. for at least 3 hours.

6. The wound dressing material according to claim 3 , wherein the gelatin is a gelatin containing not more than 10 EU/g endotoxin.

7. The wound dressing material according to claim 6 , wherein the gelatin derivative has a molar ratio of imino group/amino group ranging from 20/80 to 80/20.

8. A method for preparing the wound dressing material according to claim 6 , comprising:
preparing the gelatin derivative comprising the structure represented by the aforesaid formula (1);
spray drying a solution of the gelatin derivative or pulverizing the gelatin derivative in solid state to form particles; and
heat treating the formed particles by heating at a temperature of from 140 to 160° C. for at least 3 hours.

9. The wound dressing material according to claim 1 , wherein the gelatin derivative has a molar ratio of imino group/amino group ranging from 20/80 to 80/20.

10. A method for preparing the wound dressing material according to claim 9 , comprising:
preparing the gelatin derivative comprising the structure represented by the aforesaid formula (1);
spray drying a solution of the gelatin derivative or pulverizing the gelatin derivative in solid state to form particles; and
heat treating the formed particles by heating at a temperature of from 140 to 160° C. for at least 3 hours.

Assignees

• Nat Inst Materials Science

Inventors

• Taguchi Tetsushi
• Nishiguchi Akihiro

Classifications

• A61L15/32 Primary

  Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin {(A61L15/225 takes precedence)} · CPC title

• A61F13/02

  Adhesive bandages or dressings · CPC title

• A61L31/045

  Gelatin · CPC title

• A61L26/0038 Primary

  Gelatin · CPC title

• A61L26/0076

  Sprayable compositions · CPC title