Cohesive thin liquids to promote safe swallowing in dysphagic patients

Patent metadata

Field	Value
Publication number	US-11992035-B2
Application number	US-202016790286-A
Country	US
Kind code	B2
Filing date	Feb 13, 2020
Priority date	Dec 15, 2011
Publication date	May 28, 2024
Grant date	May 28, 2024

Abstract

Nutritional products having improved cohesiveness for promoting safer swallowing of food boluses for patients having swallowing conditions are provided as well as methods of making and using such products. The nutritional products may include nutritional compositions and high molecular weight, water-soluble polymers such that the nutritional products have extensional viscosities that provide improved cohesiveness to the nutritional products. Methods of administering such nutritional products to patients having impaired swallowing ability and/or dysphagia are also provided.

First claim

The invention is claimed as follows:

1. A method of treating an individual having a swallowing disorder, the method comprising:
administering an effective amount of a liquid nutritional product to the individual having the swallowing disorder, the liquid nutritional product comprising a nutritional composition and a plant-derived mucilage selected from the group consisting of kiwi fruit mucilage, mallow mucilage, ribwort mucilage, mullein mucilage, and mixtures thereof, the liquid nutritional product comprises an amount of the plant-derived mucilage such that the liquid nutritional product has an increased cohesiveness relative to the nutritional composition, has a shear viscosity less than about 100 mPas when measured at a shear rate of 50s −1 and has a relaxation time, determined by a Capillary Breakup Extensional Rheometry (CaBER) experiment, more than 10 milliseconds at a temperature of 20° C.

2. The method of claim 1 , wherein the shear viscosity of the liquid nutritional product is 5 mPas to 20 mPas when measured at a shear rate of 50s −1 .

3. The method of claim 1 , wherein the relaxation time of the liquid nutritional product is about 100 milliseconds to about 200 milliseconds.

4. The method of claim 1 , wherein the swallowing disorder is at least one of dysphagia or compromised saliva excretion.

5. The method of claim 1 , wherein the liquid nutritional product has a form selected from the group consisting of pharmaceutical formulations, nutritional formulations, dietary supplements, functional food and beverage products, and combinations thereof.

6. The method of claim 1 , wherein the liquid nutritional product further comprises an additional ingredient selected from the group consisting of a probiotic, a prebiotic, an amino acid, a fatty acid, a phytonutrient, an antioxidant, and mixtures thereof.

7. The method of claim 1 , wherein the plant-derived mucilage comprises kiwi fruit mucilage.

Assignees

• Nestle Sa

Inventors

• Burbidge Adam Stewart
• Engmann Jan
• Popa Nita Simina

Classifications

• A61K36/577

  Malvaceae (Mallow family) · CPC title

• A61K36/185

  Magnoliopsida (dicotyledons) · CPC title

• A23L29/271 Primary

  Curdlan; beta-1-3 glucan; Polysaccharides produced by agrobacterium or alcaligenes · CPC title

• A23L29/20 Primary

  containing gelling or thickening agents (marmalades, jams, jellies or other similar fruit or vegetable compositions A23L21/10) · CPC title

• A23L29/206

  of vegetable origin · CPC title