Particle-containing membrane and particulate electrode for analyte sensors

Patent metadata

Field	Value
Publication number	US-11918354-B2
Application number	US-201916732121-A
Country	US
Kind code	B2
Filing date	Dec 31, 2019
Priority date	Sep 19, 2008
Publication date	Mar 5, 2024
Grant date	Mar 5, 2024

Abstract

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

First claim

What is claimed is:

1. A system for continuous in vivo detection of an analyte, the system comprising:
a continuous analyte sensor comprising a working electrode configured for implantation in a host, wherein the working electrode comprises an electroactive surface, the continuous analyte sensor further comprising a membrane located over the working electrode, wherein the membrane comprises an enzyme domain and a particle-containing domain, wherein the particle-containing domain comprises a conductive component dispersed in a non-conductive component, wherein the conductive component comprises a plurality of conductive particles comprising 1 wt. % to 90 wt. % of the particle-containing domain, wherein the particle-containing domain is located more distal to the electroactive surface than the enzyme domain, and wherein the particle-containing domain is configured to electrochemically react with at least one interfering species; and
sensor electronics configured to generate a signal associated with the analyte in the host.

2. The system of claim 1 , wherein the conductive component comprises at least one material selected from the group consisting of platinum, platinum-iridium, iridium, palladium, graphite, gold, silver, silver chloride, carbon, and conductive polymers.

3. The system of claim 1 , wherein the plurality of conductive particles comprise from 10 wt. % to 40 wt. % of the particle-containing domain.

4. The system of claim 1 , wherein the non-conductive component comprises a polymer.

5. The system of claim 4 , wherein the polymer comprises an analyte-permeable polymer.

6. The system of claim 5 , wherein the analyte-permeable polymer comprises a hydrophilic polymer.

7. The system of claim 5 , wherein the analyte-permeable polymer comprises at least one of polyurethane or silicone.

8. The system of claim 1 , wherein the sensor electronics are configured to apply a potential to the particle-containing domain.

9. The system of claim 1 , wherein the analyte is glucose.

10. A method for detecting a signal associated with an analyte, the method comprising:
providing a continuous analyte sensor configured for implantation into a tissue of a host, the continuous analyte sensor comprising a working electrode and a membrane located over the working electrode, wherein the membrane comprises an enzyme domain and a particle-containing domain comprising a plurality of conductive particles from 1 wt. % to 90 wt. % of the particle-containing domain, wherein the particle-containing domain is located more distal to the working electrode than the enzyme domain;
electrochemically reacting the particle-containing domain with at least one interfering species; and
detecting a signal from the continuous analyte sensor, wherein the signal is indicative of a concentration of the analyte.

11. The method of claim 10 , wherein the continuous analyte sensor is configured to contact a biological sample.

12. The method of claim 10 , wherein the membrane is configured to allow the analyte to diffuse therethrough.

13. The method of claim 10 , wherein electrochemically reacting comprises applying a potential to the particle-containing domain.

14. The method of claim 10 , wherein the analyte is glucose.

15. The method of claim 10 , wherein the conductive particles comprises at least one material selected from the group consisting of platinum, platinum-iridium, iridium, palladium, graphite, gold, silver, silver chloride, carbon, and conductive polymers.

16. The method of claim 10 , wherein the plurality of conductive particles comprise from 10 wt. % to 40 wt. % of the particle-containing domain.

17. The method of claim 10 , wherein the particle-containing domain comprises a hydrophilic polymer.

18. The method of claim 10 , wherein the particle-containing domain comprises at least one of polyurethane or silicone.

19. The method of claim 10 , wherein electrochemically reacting the particle-containing domain with the at least one interfering species includes electrochemically oxidizing or electrochemically reducing the at least one interfering species.

20. The method of claim 10 , wherein electrochemically reacting the particle-containing domain with the at least one interfering species includes electrochemically reducing the at least one interfering species.

Assignees

• Dexcom Inc

Inventors

• Simpson Peter C
• Boock Robert J
• Wightlin Matthew
• Shults Mark C

Classifications

• A61B5/1473 Primary

  invasive, e.g. introduced into the body by a catheter · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• A61B5/14865

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title

• A61B5/6848

  Needles · CPC title