Particle-containing membrane and particulate electrode for analyte sensors

Patent metadata

Field	Value
Publication number	US-9339222-B2
Application number	US-201313907507-A
Country	US
Kind code	B2
Filing date	May 31, 2013
Priority date	Sep 19, 2008
Publication date	May 17, 2016
Grant date	May 17, 2016

Abstract

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

First claim

What is claimed is:

1. A system for continuous in vivo measurement of an analyte in a host, the system comprising:
a continuous analyte sensor configured for implantation in a host and configured to generate a signal indicative of an analyte concentration; and
a layer disposed over at least a portion of the sensor, wherein the layer comprises a particle-containing domain comprising a metal, wherein the particle-containing domain is configured to react with at least one interfering species.

2. The system of claim 1 , wherein the particle-containing domain is more distal to the sensor than other domains of the layer.

3. The system of claim 1 , wherein the particle-containing domain comprises at least one material selected from the group consisting of platinum, platinum-iridium, iridium, palladium, graphite, gold, silver, silver chloride, carbon, and conductive polymers.

4. The system of claim 1 , wherein the metal comprises sputtered metal.

5. The system of claim 4 , wherein the sputtered metal is platinum.

6. The system of claim 1 , wherein the particle-containing domain comprises a conductive particles concentration that is sufficient for the particle-containing domain to function as a conductive film.

7. The system of claim 1 , wherein the particle-containing domain is configured to reduce flux therethrough of hydrogen peroxide.

8. The system of claim 1 , wherein the particle-containing domain is non-powered.

9. The system of claim 1 , wherein the particle-containing domain is powered.

10. The system of claim 9 , wherein the sensor electronics are configured to apply a potential to the particle-containing domain.

11. The system of claim 1 , wherein the layer comprises an analyte-permeable polymer.

12. The system of claim 11 , wherein the analyte-permeable polymer comprises a hydrophilic polymer.

13. The system of claim 11 , wherein the analyte-permeable polymer comprises at least one of polyurethane or silicone.

14. The system of claim 1 , wherein the interfering species interferes with measurement of the analyte concentration to produce a signal that does not accurately represent the analyte concentration.

15. The system of claim 1 , wherein the interfering species is a reactive metabolic species.

16. The system of claim 1 , wherein the interfering species is a reactive oxygen species.

17. The system of claim 1 , wherein the interfering species is a reactive nitrogen species.

18. The system of claim 1 , wherein the interfering species is H 2 O 2 .

Assignees

• Dexcom Inc

Inventors

• Simpson Peter C
• Boock Robert J
• Wightlin Matthew D
• Shults Mark C

Classifications

• A61B5/6848

  Needles · CPC title

• A61B2562/028

  Microscale sensors, e.g. electromechanical sensors [MEMS] · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• A61B5/1473 Primary

  invasive, e.g. introduced into the body by a catheter · CPC title

• A61B5/14865

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title