Particle-containing membrane and particulate electrode for analyte sensors

Patent metadata

Field	Value
Publication number	US-10028684-B2
Application number	US-201715711863-A
Country	US
Kind code	B2
Filing date	Sep 21, 2017
Priority date	Sep 19, 2008
Publication date	Jul 24, 2018
Grant date	Jul 24, 2018

Abstract

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

First claim

What is claimed is:

1. A sensor for measuring an analyte concentration in a host, the sensor comprising:
an elongated body configured to be implanted at least in part in a host, wherein the elongated body comprises:
a substrate;
a first layer covering at least a portion of the substrate, wherein the first layer comprises a first conductive material, wherein a portion of the first layer comprises a first electroactive surface;
a second layer covering at least a portion of the first layer, wherein the second layer comprises an insulating material;
a third layer covering at least a portion of the second layer, wherein the third layer comprises a second conductive material, wherein a portion of the second layer comprises a second electroactive surface; and
a fourth layer covering at least a portion of the third layer, wherein the fourth layer comprise an insulating material;
wherein the first electroactive surface and the second electroactive surface are separated along a longitudinal axis of the elongated body by at least a portion of the fourth layer.

2. The sensor of claim 1 , wherein the elongated body further comprises a fifth layer, wherein the fifth layer comprises a conductive material.

3. The sensor of claim 2 , wherein the fifth layer comprises a silver-containing material.

4. The sensor of claim 1 , wherein the conductive material of the first layer comprises a platinum-containing material, wherein the conductive material of the third layer comprises a platinum-containing material.

5. The sensor of claim 1 , further comprising sensor electronics configured to process a signal received from the working electrode, wherein the sensor electronics are configured to apply a potential of from about 0.1V to about 0.8V to the working electrode.

6. The sensor of claim 5 , wherein the sensor electronics are configured to apply a potential of from about 0.3V to about 0.7V to the working electrode.

7. The sensor of claim 5 , wherein the sensor electronics are configured to apply a potential of from about 0.3V to about 0.5V to the working electrode.

Assignees

• Dexcom Inc

Inventors

• Simpson Peter C
• Boock Robert J
• Wightlin Matthew
• Shults Mark C

Classifications

• A61B5/6848

  Needles · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• A61B5/14865

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title

• A61B2562/028

  Microscale sensors, e.g. electromechanical sensors [MEMS] · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title