Particle-containing membrane and particulate electrode for analyte sensors

Patent metadata

Field	Value
Publication number	US-10028683-B2
Application number	US-201414508990-A
Country	US
Kind code	B2
Filing date	Oct 7, 2014
Priority date	Sep 19, 2008
Publication date	Jul 24, 2018
Grant date	Jul 24, 2018

Abstract

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

First claim

What is claimed is:

1. A system for continuous in vivo measurement of glucose in a host, the system comprising:
a continuous glucose sensor configured for implantation in a host and configured to measure in vivo a signal indicative of a glucose concentration, wherein the continuous glucose sensor comprises an electrode, wherein the electrode comprises a glucose-impermeable material and conductive particles distributed within the glucose-impermeable material, wherein each of the conductive particles has a three-dimensional electroactive surface;
a biocompatible membrane located over at least a portion of the electrode, wherein the biocompatible membrane is configured to reduce a flux of glucose therethrough; and
sensor electronics operably connected to the continuous glucose sensor, wherein the sensor electronics are configured to process the signal from the continuous glucose sensor.

2. The system of claim 1 , wherein the electrode comprises a plurality of sensing elements, wherein the sensor electronics are configured to determine the glucose concentration by averaging or integrating signals from the plurality of sensing elements.

3. The system of claim 1 , wherein the electroactive surfaces all have a substantially equal area.

4. The system of claim 1 , wherein the electroactive surfaces are each spaced apart from at least one adjacent electroactive surface by a substantially equal distance.

5. The system of claim 1 , wherein the biocompatible membrane comprises polyurethane.

6. The system of claim 1 , wherein the continuous glucose sensor has a planar shape.

7. The system of claim 1 , wherein the electrode comprises a mixture comprising of metal oxide and carbon.

8. The system of claim 7 , wherein the mixture further comprises platinum.

9. The system of claim 1 , wherein the sensor is configured to apply a bias potential from about 0.1 V to about 0.6 V.

10. The system of claim 9 , wherein the sensor is configured to apply a bias potential at around 0.35 V.

11. The system of claim 2 , wherein the sensing elements are spaced along a substantial length of an in vivo portion of the continuous glucose sensor.

12. The system of claim 2 , wherein the plurality of sensing elements comprise more than two electroactive surfaces.

13. The system of claim 2 , wherein the plurality of sensing elements comprise more than three electroactive surfaces.

14. The system of claim 2 , wherein the plurality of sensing elements are spaced apart within a diffusion distance of a measured glucose.

Assignees

• Dexcom Inc

Inventors

• Simpson Peter C
• Boock Robert J
• Wightlin Matthew D
• Shults Mark C

Classifications

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• A61B2562/028

  Microscale sensors, e.g. electromechanical sensors [MEMS] · CPC title

• A61B5/6848

  Needles · CPC title

• A61B5/1473 Primary

  invasive, e.g. introduced into the body by a catheter · CPC title

• A61B5/14865

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title