Enclosed desorption electrospray ionization probes and method of use thereof

Patent metadata

Field	Value
Publication number	US-11903707-B2
Application number	US-202217692613-A
Country	US
Kind code	B2
Filing date	Mar 11, 2022
Priority date	Jun 3, 2011
Publication date	Feb 20, 2024
Grant date	Feb 20, 2024

Abstract

The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

First claim

What is claimed is:

1. An ionization device, the device comprising:
an elongate tube comprising a proximal end and open distal end, wherein the elongate tube further comprises an opening in a sidewall located at a distal portion of the elongate tube;
an interface component comprising a first end configured to mate with an inlet of a mass spectrometer and a second end configured to mate with the proximal end of the elongate tube; and
a desorption electrospray ionization (DESI) source comprising a discharge tube;
wherein the device is configured such that the proximal end of the elongate tube is inserted into the second end of the interface component and a portion of the discharge tube is inserted through the sidewall of the elongate tube and terminates prior to the open distal end.

2. The ionization device of claim 1 , wherein the DESI source produces a DESI-active spray in a first direction within the elongate tube, and a velocity of the DESI-active spray in the first direction is reduced by a gas flow in an opposite direction generated in the elongate tube by a mass spectrometer that is coupled to the ionization device via the proximal end of the elongate tube.

3. The ionization device of claim 1 , wherein the elongate tube is a catheter.

4. The ionization device of claim 1 , wherein the portion of the discharge tube is sealed within the elongate tube.

5. The ionization device of claim 1 , wherein the distal portion of the elongate tube is configured to interact with a surface.

6. The ionization device of claim 5 , wherein the surface is tissue.

7. The ionization device of claim 2 , wherein the mass spectrometer is a bench top mass spectrometer or a handheld mass spectrometer.

8. The ionization device of claim 2 , wherein the DESI-active spray is generated by an electrospray device.

9. The ionization device of claim 2 , wherein the source produces the DESI-active spray without voltage.

10. The ionization device of claim 2 , wherein the DESI-active spray comprises water.

Assignees

• Purdue Research Foundation

Inventors

• Cooks Robert Graham
• Ouyang Zheng
• Chen Chien-Hsun
• Lin Ziqing
• Eberlin Livia Schiavinato

Classifications

• A61B5/1477 Primary

  non-invasive · CPC title

• A61B10/0045 Primary

  Devices for taking samples of body liquids · CPC title

• A61M11/00

  Sprayers or atomisers specially adapted for therapeutic purposes (in general B05B; {aerosol containers B65D83/14}) · CPC title

• A61M25/00

  Catheters; Hollow probes (dilators A61M29/00; {peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00} ; for measuring or testing A61B; {materials for catheters A61L29/00}) · CPC title

• G01N33/4833

  of solid biological material, e.g. tissue samples, cell cultures (tissue in vivo A61B5/00; cell suspensions G01N33/48735) · CPC title