Syringa pubescens microphylla seed extract composition and its application in antibiotic-resistant infections

Patent metadata

Field	Value
Publication number	US-11712457-B2
Application number	US-202117173622-A
Country	US
Kind code	B2
Filing date	Feb 11, 2021
Priority date	Nov 25, 2020
Publication date	Aug 1, 2023
Grant date	Aug 1, 2023

Abstract

A Syringa microphylla seed extract includes the following components by weight based on a total weight of the Syringa microphylla seed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing the Syringa microphylla seed extract is disclosed. A composition for treating antibiotic-resistant infections that includes the Syringa microphylla seed extract is also disclosed.

First claim

What is claimed is:

1. A composition for treating antibiotic-resistant infections, comprising in a dosage form and therapeutically effective amounts therefor:
(i) a Syringa pubescens microphylla seed extract,
wherein the seed extract has the identifying features of a Syringa pubescens microphylla seed methanolic extract prepared by treating said seed with sequential steps of pulverizing, sieving, extracting with petroleum ether, heating under reflux, filtering, and extracting with said methanol, and
wherein the seed extract comprises based on a total weight thereof: 0.4944-0.7142 mg/g of echinacoside; 6.624-7.617 mg/g of oleuropein; 0.4276-0.6309 mg/g of verbascoside; 3.927-4.684 mg/g of syringin; and 4.505-5.250 mg/g of forsythiaside B; and

(ii) a pharmaceutically acceptable carrier or diluent, wherein the pharmaceutically acceptable carrier or diluent is one or more selected from the group consisting of olive oil, corn oil, castor oil, cotton seed oil, wheat germ oil, cacao oil, white soft paraffin, solid paraffin, liquid paraffin, carnauba wax, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, polyethylene glycol, and polyoxyethylene alcohol; and
wherein the dosage form is a powder or tablet.

Assignees

• Zhao Qianqian
• Li Jialin
• Yang Dan
• Li Jingyi
• Xin Liang
• Shi Chunyang
• Xie Xiaolin
• Zhang Dezhu
• Bian Ruina
• Ju Xingke
• Liang Chengyuan
• Li Yanjun
• Zeng Qiao
• Univ Shaanxi Science & Tech

Inventors

• Zhao Qianqian
• Li Jialin
• Yang Dan
• Li Jingyi
• Xin Liang
• Shi Chunyang
• Xie Xiaolin
• Zhang Dezhu
• Bian Ruina
• Ju Xingke
• Liang Chengyuan
• Li Yanjun
• Zeng Qiao

Classifications

• A61K36/63 Primary

  Oleaceae (Olive family), e.g. jasmine, lilac or ash tree · CPC title

• A61K31/7034

  attached to a carbocyclic compound, e.g. phloridzin · CPC title

• A61K31/7048

  having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin} · CPC title

• A61K47/44

  Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14) · CPC title

• A61P31/04

  Antibacterial agents · CPC title