Hydroxytyrosol combinations for enhancing mitochondrial function and energy production

Patent metadata

Field	Value
Publication number	US-9446006-B2
Application number	US-201414450073-A
Country	US
Kind code	B2
Filing date	Aug 1, 2014
Priority date	Apr 17, 2009
Publication date	Sep 20, 2016
Grant date	Sep 20, 2016

Abstract

Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract.can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.

First claim

What is claimed is:

1. A method of increasing mitochondria biogenesis in a mammal comprising:
(a) administering to the mammal in need of increased mitochondria biogenesis an effective amount of a composition comprising a dosage amount of 10-200 mg of hydroxytyrosol in combination with a dosage amount of 50-450 mg of caffeine; and
(b) observing a mitochondria biogenesis effect.

2. The method according to claim 1 , wherein the hydroxytyrosol is from an olive extract.

3. The method according to claim 1 , wherein the composition is a nutraceutical or food composition.

4. The method according to claim 1 , wherein the composition is a veterinary composition.

5. The method according to claim 1 , wherein the mitochondria biogenesis effect comprises observations that the method helps reduce muscle fatigue; helps reduce muscle soreness; complements an immediate short term effect of caffeine with a sustained effect on energy generation; helps promote energy generation from fat; helps lower plasma lactate during exercise; helps maintain muscle force in conditions of oxidative stress; helps protect against exercise-induced oxidative stress; helps the body to find more energy without getting too much caffeine; gives long-lasting energy; helps boost body's own energy production; helps maintain more even energy levels throughout the day; provide for immediate and sustained energy; helps the body to adapt to exercise; helps prepare the body for exercise goals; helps revamp the body's shape; facilitates a restart of an exercise program; helps one to get going again; helps one feel more energetic; helps one feel more active; supports one's zest for action; helps one cope with a busy lifestyle; increased muscle work capacity; improved aerobic capacity; enhanced physical performance; enhanced exercise performance; improved running endurance; improved running distance and/or improved running time; or stimulates energy formation from nutrients.

6. The method according to claim 5 , wherein the composition is a veterinary composition.

Assignees

• Fowler Ann
• Friedel Angelika
• Knutti Darko
• Kuratli Karin
• Raederstorff Daniel
• Wang-Schmidt Ying
• Wertz Karin
• Dsm Ip Assets Bv

Inventors

• Fowler Ann
• Friedel Angelika
• Knutti Darko
• Kuratli Karin
• Raederstorff Daniel
• Wang-Schmidt Ying
• Wertz Karin

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61P21/00

  Drugs for disorders of the muscular or neuromuscular system · CPC title

• A61P1/16

  for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics · CPC title