Zinc / amino acid-functionalized silica

Patent metadata

Field	Value
Publication number	US-11186489-B2
Application number	US-201816206671-A
Country	US
Kind code	B2
Filing date	Nov 30, 2018
Priority date	Dec 5, 2017
Publication date	Nov 30, 2021
Grant date	Nov 30, 2021

Abstract

Disclosed herein is zinc/amino acid functionalized silica, compositions comprising the same, and oral care methods and uses for such compositions.

First claim

What is claimed:

1. A functionalized silica particle comprising a prophy silica having an average particle size of 5 to 20 microns; and a zinc-amino acid complex adsorbed to a surface of said silica, wherein the zinc-amino acid complex comprises zinc-lysine complex and/or zinc-arginine complex having a structure selected from one or more of [Zn(AA) 3 X] + , [Zn(AA) 2 X] + , [Zn(AA)X] + , [Zn(AA) 3 ] 2+ , [Zn(AA) 2 ] 2+ , [Zn(AA)] 2+ , wherein AA is lysine or arginine and wherein X is a halide, or another monovalent anion.

2. The functionalized silica particle according to claim 1 , wherein the zinc-amino acid complex comprises zinc-lysine complex having a structure selected from one or more of [Zn(AA) 3 X] + , [Zn(AA) 2 X] + , [Zn(AA)X] + , [Zn(AA) 3 ] 2+ , [Zn(AA) 2 ] 2+ , [Zn(AA)] 2+ , wherein AA is lysine, and wherein X is a halide or another monovalent anion.

3. The functionalized silica particle according to claim 1 , wherein the zinc-amino acid complex comprises zinc-arginine complex having a structure selected from one or more of [Zn(AA) 3 X] + , [Zn(AA) 2 X] + , [Zn(AA)X] + , [Zn(AA) 3 ] 2+ , [Zn(AA) 2 ] 2+ , [Zn(AA)] 2+ , wherein AA is arginine, and wherein X is a halide, or another monovalent anion.

4. The functionalized silica particle according to claim 2 wherein X is chloride.

5. The functionalized silica particle according to claim 1 , wherein the silica has an N 2 BET surface area of 200-1200 m 2 /g.

6. The functionalized silica particle according to claim 1 , wherein the silica has an N 2 BET surface area of 600 to 800 m 2 /g and an average particle size of 14 to 18 microns.

7. The functionalized silica particle according to claim 1 , wherein the functionalized silica contains from 0.1 to 10 mg of zinc/amino acid per 100 mg of silica.

8. The functionalized silica particle according to claim 1 , comprising from about 0.1 wt % to about 30 wt % zinc/amino acid, optionally wherein the zinc to amino acid molar ratio is from 5:1 to 1:5.

9. An oral care composition comprising a functionalized silica particle according to claim 1 .

10. The oral care composition according to claim 9 , wherein the composition comprises from 0.1 to 50% by weight of functionalized silica particles.

11. The oral care composition according to claim 9 , further comprising a metal salt.

12. The oral care composition according to claim 11 , wherein the metal salt comprises zinc oxide, zinc citrate, zinc lactate, zinc phosphate, or a combination thereof.

13. The oral care composition according to claim 9 , further comprising a basic amino acid, in free or orally acceptable salt form.

14. The oral care composition according to claim 9 , in the form of a toothpaste, gel, mouthwash, powder, cream, strip, thin film, or gum.

15. The oral care composition according to claim 14 , in the form of a toothpaste, gel or mouthwash.

16. The oral care composition according to claim 9 , further comprising an effective amount of a fluoride ion source.

17. A method of treating a disease, disorder or condition of the oral cavity, comprising the step of administering to a patient in need thereof an oral care composition according to claim 9 , to deliver zinc to the oral cavity, optionally, wherein said patient suffers from a disease, disorder or condition of the oral cavity, such as gingivitis, periodontitis, halitosis, cavity formation, enamel erosion, and/or oral infection.

18. The functionalized silica particle according to claim 4 , wherein the functionalized silica is made by incubating silica particles in an aqueous solution of a zinc-amino acid-halide complex having the structure [Zn(lysine) 2 Cl] + Cl −.

Assignees

• Colgate Palmolive Co

Inventors

• Dubovoy Viktor
• Brinzari Tatiana
• Stranick Michael
• Pan Long
• Subramanyam Ravi

Classifications

• A61K8/0279

  Porous; Hollow · CPC title

• C01B33/18 Primary

  Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof (preparation of aerogels by dehydrating gels C01B33/158; treatment to enhance the pigmenting or filling properties C09C) · CPC title

• A61K8/27

  Zinc; Compounds thereof · CPC title

• A61K8/25

  Silicon; Compounds thereof · CPC title

• A61K8/44

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title