Oral gel comprising zinc-amino acid complex

Patent metadata

Field	Value
Publication number	US-9763865-B2
Application number	US-201214653880-A
Country	US
Kind code	B2
Filing date	Dec 19, 2012
Priority date	Dec 19, 2012
Publication date	Sep 19, 2017
Grant date	Sep 19, 2017

Abstract

Disclosed herein are dentifrices comprising a zinc amino acid halide, which provide a precipitate of zinc oxide upon use with dilution with water and/or saliva. Methods of making and using the dentifrices are also provided.

First claim

The invention claimed is:

1. An oral gel comprising a zinc amino acid halide complex, wherein the amino acid is lysine, and the zinc-amino acid-halide complex is a zinc lysine chloride complex, and wherein the zinc lysine chloride complex has the chemical structure [Zn(C 6 H 14 N 2 O 2 )Cl] + Cl − , either in a solution comprising the cation [Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + and a chloride anion, or in solid salt form, optionally in mono-or dihydrate form.

2. The oral gel of claim 1 , wherein the zinc-amino acid-halide complex is formed from precursors.

3. The oral gel of claim 2 , and wherein the precursors are a zinc ion source, an amino acid source, and a halide source.

4. The oral gel of claim 3 , wherein the halide source is part of the zinc ion source, the amino acid source, or a halogen acid.

5. The oral gel of claim 3 , wherein the zinc ion source and amino acid source form the complex in situ after the composition is applied.

6. The oral gel of claim 1 , wherein the amino acid is lysine, in free or orally acceptable salt form.

7. The oral gel of claim 1 , wherein the amount of zinc is 0.05-4% by weight of the composition.

8. The oral gel of claim 1 , wherein the zinc is solubilized, such that the gel is substantially clear, which provides a zinc precipitate upon use and dilution with saliva and/or rinsing.

9. The oral gel of claim 1 , further comprising an effective amount of a fluoride ion source.

10. The oral gel of claim 1 , further comprising an orally acceptable base comprising ingredients selected from one or more of abrasives, buffering agents, humectants, surfactants, thickeners, gum strips or fragments, breath fresheners, flavoring, fragrance, coloring, antibacterial agents, whitening agents, agents that interfere with or prevents bacterial attachment, calcium sources, phosphate sources, orally acceptable potassium salts, and anionic polymers.

11. The oral gel of claim 1 , wherein the pH of the gel is from pH 6 to pH 8.

12. The oral gel of claim 1 , wherein the oral gel is a substantially clear gel.

13. A method of manufacturing an oral gel according to claim 1 , comprising the steps of adding a zinc ion source together with an amino acid in complex during manufacture.

14. A method of treating or reducing dental enamel erosion cleaning the teeth, reducing bacterially-generated biofilm and plaque, reducing gingivitis, inhibiting tooth decay and formation of cavities, and/or reducing dentinal hypersensitivity comprising applying an oral gel according to claim 1 to the teeth, and optionally then rinsing with water or aqueous solution sufficient to trigger precipitation of zinc oxide from the gel.

Assignees

• Colgate Palmolive Co

Inventors

• Pan Long
• Yuan Shaotang
• Pilch Shira
• Masters James G
• Liu Zhiqiang
• Patel Vyoma

Classifications

• A61K8/27 Primary

  Zinc; Compounds thereof · CPC title

• A61K8/731

  Cellulose; Quaternized cellulose derivatives · CPC title

• A61K2800/58

  Metal complex; Coordination compounds · CPC title

• A61K8/21

  Fluorides; Derivatives thereof · CPC title

• A61K8/44 Primary

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title