Zinc amino acid halide complex with cysteine

Patent metadata

Field	Value
Publication number	US-9504858-B2
Application number	US-201314650907-A
Country	US
Kind code	B2
Filing date	Nov 7, 2013
Priority date	Dec 19, 2012
Publication date	Nov 29, 2016
Grant date	Nov 29, 2016

Abstract

Provided are compositions, e.g., oral and personal care products, comprising (i) a zinc amino acid halide complex, and (ii) cysteine in free or in orally or cosmetically acceptable salt form, together with methods of making and using the same.

First claim

The invention claimed is:

1. A composition comprising (i) a zinc (amino acid or trialkyl glycine) halide complex and (ii) cysteine in free or in orally or cosmetically acceptable salt form.

2. The composition according to claim 1 , wherein the zinc (amino acid or tralkyl glycine) halide is formed from precursors, wherein the precursors are a zinc ion source, an amino acid source, and a halide source, wherein the halide source can be part of the zinc ion source, the amino acid source, or a halogen acid.

3. The composition according to claim 2 , wherein the zinc ion source is at least one of zinc oxide, zinc chloride, zinc carbonate, zinc nitrate, zinc citrate, and zinc phosphate.

4. The composition according to claim 2 , wherein the amino acid source is at least one of a basic amino acid, lysine, arginine, and glycine.

5. The composition according to claim 1 , wherein the trialkyl glycine is a C 1 -C 4 alkyl glycine or trimethyl glycine.

6. The composition according to claim 1 wherein the zinc amino acid halide is made by combining zinc oxide with an amino acid hydrohalide.

7. The composition according to claim 1 wherein the zinc amino acid halide has the formula Zn(Amino Acid) 2 Hal 2 or Zn(Amino Acid) 3 Hal 2 , wherein Zn is a divalent zinc ion and Hal is a halide ion.

8. The composition according to claim 1 wherein the zinc amino acid halide complex is [Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + Cl − .

9. The composition according to claim 1 which upon dilution with water, provides a precipitate comprising zinc oxide in complex with cysteine, and optionally additionally comprising zinc oxide, zinc carbonate, and mixtures thereof.

10. The composition according to claim 1 wherein the total amount of zinc present in the composition is 0.2 to 8% by weight of the composition.

11. The composition according to claim 1 , wherein the cysteine is cysteine hydrohalide, optionally cysteine hydrochloride.

12. The composition according to claim 1 which is an antiperspirant or deodorant product, further comprising a cosmetically acceptable carrier.

13. A method of killing bacteria, reducing perspiration, and/or reducing body odor comprising applying to skin an effective amount of the composition of claim 12 .

14. The composition of claim 1 which is a personal care product selected from liquid hand soap, body wash, dermal lotions, dermal creams, and dermal conditioners further comprising a cosmetically acceptable carrier.

15. A method of killing bacteria, treating or reducing the incidence of acne or topical skin infections, or to provide a visual signal when washing, comprising washing the skin with water and an effective amount of the composition of claim 14 .

16. The composition of claim 1 which is an oral care product, further comprising an orally acceptable carrier.

17. A method to reduce and inhibit acid erosion of the enamel, clean the teeth, reduce bacterially-generated biofilm and plaque, reduce gingivitis, inhibit tooth decay and formation of cavities, and/or reduce dentinal hypersensitivity comprising applying an effective amount of a composition according to claim 16 to the oral cavity of a person in need thereof.

Assignees

• Colgate Palmolive Co

Inventors

• Yuan Shaotang
• Pan Long
• Du-Thumm Laurence D

Classifications

• A61Q11/00 Primary

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K2300/00

  Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 · CPC title

• A61K8/447 Primary

  containing sulfur · CPC title

• A61K33/30

  Zinc; Compounds thereof · CPC title

• A61K31/198

  Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) · CPC title