Zinc amino acid halide mouthwashes

Patent metadata

Field	Value
Publication number	US-9980890-B2
Application number	US-201214653324-A
Country	US
Kind code	B2
Filing date	Dec 19, 2012
Priority date	Dec 19, 2012
Publication date	May 29, 2018
Grant date	May 29, 2018

Abstract

Disclosed herein are mouthwashes comprising a complex of a zinc ion source acid. Methods of making and using the compositions are also provided.

First claim

The invention claimed is:

1. A mouthwash comprising a zinc amino acid halide complex, wherein the zinc amino acid halide complex is a zinc lysine chloride complex having the chemical structure [Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + Cl − .

2. The mouthwash of claim 1 , wherein the zinc amino acid halide complex is formed from precursors.

3. The mouthwash of claim 2 , wherein the precursors are a zinc ion source, an amino acid source, and a halide source.

4. The mouthwash of claim 3 , wherein the halide source is part of the zinc ion source, the amino acid source, or a halogen acid.

5. The mouthwash of claim 3 , wherein the lysine source is in a free or orally acceptable acid addition salt form.

6. The mouthwash of claim 1 , wherein the amount of zinc is 0.05-4% by weight.

7. The mouthwash of claim 1 , wherein the zinc is solubilized in the formulation, but provides a zinc precipitate upon use and dilution with saliva and/or rinsing.

8. The mouthwash of claim 1 , wherein the zinc lysine chloride complex having the chemical structure [Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + Cl − is in solution of the cation ([Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + ) and the chloride anion, or in solid salt form, optionally in mono- or dihydrate form.

9. The mouthwash of claim 1 , further comprising an effective amount of a fluoride ion source.

10. The mouthwash of claim 1 further comprising an orally acceptable base comprising ingredients selected from one or more of buffering agents, humectants, surfactants, thickeners, breath fresheners, flavoring, fragrance, coloring, antibacterial agents, whitening agents, agents that interfere with or prevent bacterial attachment, calcium sources, phosphate sources, orally acceptable potassium salts, and anionic polymers.

11. The mouthwash of claim 1 , further comprising cocamidopropyl betaine.

12. The mouthwash of claim 1 , wherein the pH of the mouthwash is from pH 4 to pH 8.

13. The mouthwash of claim 1 , wherein the zinc-lysine-chloride complex is in an amount to provide 0.5-2% zinc by weight of the mouthwash, and the mouthwash further comprises humectant in an amount of 10-25% by weight, non-ionic surfactant in an amount of 0.1-1% by weight, and sweetener, flavorings, and water.

14. The mouthwash of claim 1 , wherein the weight ratio of the zinc amino acid halide complex to water is from about 1:6 to about 1:1.

15. A method of manufacturing a mouthwash composition according to claim 1 , comprising the step of adding the zinc lysine chloride complex to the mouthwash base during manufacture.

16. A method of treating or reducing dental enamel erosion cleaning the teeth, reducing bacterially-generated biofilm and plaque, reducing gingivitis, inhibiting tooth decay and formation of cavities, and/or reducing dentinal hypersensitivity comprising applying a mouthwash according to claim 1 to the teeth.

17. The method of claim 16 further comprising the step of rinsing with sufficient water or aqueous solution to trigger precipitation of zinc oxide from the mouthwash.

Assignees

• Colgate Palmolive Co

Inventors

• Pan Long
• Yuan Shaotang
• Pilch Shira
• Masters James G
• Liu Zhiqiang

Classifications

• A61K8/44 Primary

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title

• A61K8/442

  substituted by amido group(s) · CPC title

• A61K8/21

  Fluorides; Derivatives thereof · CPC title

• A61K2800/58

  Metal complex; Coordination compounds · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title