Fabrication and self-aligned local functionalization of nanocups and various plasmonic nanostructures on flexible substrates for implantable and sensing applications

Patent metadata

Field	Value
Publication number	US-11002908-B2
Application number	US-201615333062-A
Country	US
Kind code	B2
Filing date	Oct 24, 2016
Priority date	Dec 9, 2014
Publication date	May 11, 2021
Grant date	May 11, 2021

Abstract

Methods for fabricating flexible substrate nanostructured devices are disclosed. The nanostructures comprise nano-pillars and metallic bulbs or nano-apertures. The nanostructures can be functionalized to detect biological entities. The flexible substrates can be rolled into cylindrical tubes for detection of fluidic samples.

First claim

What is claimed is:

1. A structure comprising:
a flexible substrate; and
a plurality of metallic nanocups on the flexible substrate, each metallic nanocup comprising a concave surface forming a cavity external to the flexible substrate, and a convex surface internal to the flexible substrate; and
a functionalization layer on the concave surface of the metallic nanocups,
wherein the flexible substrate is rolled in a spiral fashion to form a cylindrical tube to extend an effective interaction area between the functionalization layer and a liquid sample, the plurality of metallic nanocups being on an internal surface of the cylindrical tube, and
wherein the cylindrical tube is encapsulated in a flexible, transparent outer layer.

2. The structure of claim 1 , wherein the metallic nanocups are Au nanocups.

3. The structure of claim 1 , wherein the flexible substrate is made of polydimethylsiloxane.

4. The structure of claim 1 , wherein the flexible substrate is transparent to optical waves.

5. The structure of claim 1 , wherein a lateral diameter of the concave surface of the metallic nanocups is less than 500 nm.

6. The structure of claim 1 , wherein a depth of the concave surface of the metallic nanocups is less than 500 nm.

7. The structure of claim 1 , wherein a first portion of the plurality of metallic nanocups is facing a second portion of the plurality of metallic nanocups.

8. The structure of claim 7 , wherein the cylinder is configured to allow a fluid flow within the cylinder.

9. The structure of claim 8 , wherein the cylinder is configured to act as a waveguide for optical waves within the cylinder.

10. A structure, comprising:
a flexible substrate;
a plurality of metallic nanocups on the flexible substrate, each metallic nanocup comprising a concave surface forming a cavity external to the flexible substrate, and a convex surface internal to the flexible substrate; and
a functionalization layer on the concave surface of the metallic nanocups,
wherein the flexible substrate is rolled to form a cylinder having the plurality of metallic nanocups on an internal surface of the cylinder, and
wherein the cylinder is encapsulated in a flexible, transparent outer layer.

11. The structure of claim 10 , wherein the metallic nanocups are Au nanocups.

12. The structure of claim 10 , wherein the flexible substrate is made from polydimethylsiloxane.

13. The structure of claim 10 , wherein the flexible substrate is transparent to optical waves.

14. The structure of claim 10 , wherein a lateral diameter of the concave surface of the metallic nanocups is less than 500 nm.

15. The structure of claim 10 , wherein a depth of the concave surface of the metallic nanocups is less than 500 nm.

16. The structure of claim 10 , wherein a first portion of the plurality of metallic nanocups is facing a second portion of the plurality of metallic nanocups.

17. The structure of claim 10 , wherein the cylinder is configured to allow a fluid flow within the cylinder.

18. The structure of claim 10 , wherein the cylinder is configured to act as a waveguide for optical waves within the cylinder.

Assignees

• California Inst Of Technonolgy
• California Inst Of Techn

Inventors

• Chang Chieh-Feng
• Walavalkar Sameer
• Fraser Scott E
• Scherer Axel

Classifications

• H10P50/268

  of silicon-containing layers · CPC title

• H10P14/69215

  the material being a silicon oxide, e.g. SiO2 · CPC title

• B82Y40/00 Primary

  Manufacture or treatment of nanostructures · CPC title

• G02B6/1226 Primary

  involving surface plasmon interaction · CPC title

• G01N21/658

  enhancement Raman, e.g. surface plasmons · CPC title